Dynamics of a Class of HIV Infection Models with Cure of Infected Cells in Eclipse Stage

Acta Biotheor. 2015 Dec;63(4):363-80. doi: 10.1007/s10441-015-9263-y. Epub 2015 Jun 17.

Abstract

In this paper, we propose two HIV infection models with specific nonlinear incidence rate by including a class of infected cells in the eclipse phase. The first model is described by ordinary differential equations (ODEs) and generalizes a set of previously existing models and their results. The second model extends our ODE model by taking into account the diffusion of virus. Furthermore, the global stability of both models is investigated by constructing suitable Lyapunov functionals. Finally, we check our theoretical results with numerical simulations.

Keywords: Diffusion; Global stability; HIV; Nonlinear incidence rate.

MeSH terms

  • Computer Simulation
  • HIV / physiology*
  • HIV Infections / prevention & control*
  • HIV Infections / virology*
  • Humans
  • Models, Theoretical*
  • Virus Replication / physiology*