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Page 1
Gain-of-Function Claims for Type-2-Diabetes-Associated Coding Variants in SLC16A11 Are Not Supported by the Experimental Data.
Cell Rep. 2019 Oct 15;29(3):778-780. doi: 10.1016/j.celrep.2019.09.021.
Cell Rep. 2019.
PMID: 31618643
Free article.
Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica.
Hoch E, Levy M, Hershfinkel M, Sekler I.
Hoch E, et al.
Int J Mol Sci. 2020 Jan 22;21(3):734. doi: 10.3390/ijms21030734.
Int J Mol Sci. 2020.
PMID: 31979155
Free PMC article.
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Zinc transporter 10 (ZnT10)-dependent extrusion of cellular Mn2+ is driven by an active Ca2+-coupled exchange.
Levy M, Elkoshi N, Barber-Zucker S, Hoch E, Zarivach R, Hershfinkel M, Sekler I.
Levy M, et al. Among authors: hoch e.
J Biol Chem. 2019 Apr 12;294(15):5879-5889. doi: 10.1074/jbc.RA118.006816. Epub 2019 Feb 12.
J Biol Chem. 2019.
PMID: 30755481
Free PMC article.
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Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH; MEDIA Consortium; SIGMA T2D Consortium; Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES.
Rusu V, et al. Among authors: hoch e.
Cell. 2017 Jun 29;170(1):199-212.e20. doi: 10.1016/j.cell.2017.06.011.
Cell. 2017.
PMID: 28666119
Free PMC article.
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The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation.
Fujimoto S, Tsuji T, Fujiwara T, Takeda TA, Merriman C, Fukunaka A, Nishito Y, Fu D, Hoch E, Sekler I, Fukue K, Miyamae Y, Masuda S, Nagao M, Kambe T.
Fujimoto S, et al. Among authors: hoch e.
Biochem J. 2016 Sep 1;473(17):2611-21. doi: 10.1042/BCJ20160324. Epub 2016 Jun 14.
Biochem J. 2016.
PMID: 27303047
Free PMC article.
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Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporter.
Ohana E, Hoch E, Keasar C, Kambe T, Yifrach O, Hershfinkel M, Sekler I.
Ohana E, et al. Among authors: hoch e.
J Biol Chem. 2009 Jun 26;284(26):17677-86. doi: 10.1074/jbc.M109.007203. Epub 2009 Apr 14.
J Biol Chem. 2009.
PMID: 19366695
Free PMC article.
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Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.
Hoch E, Lin W, Chai J, Hershfinkel M, Fu D, Sekler I.
Hoch E, et al.
Proc Natl Acad Sci U S A. 2012 May 8;109(19):7202-7. doi: 10.1073/pnas.1200362109. Epub 2012 Apr 23.
Proc Natl Acad Sci U S A. 2012.
PMID: 22529353
Free PMC article.
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