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Validation of a suite of ERP and QEEG biomarkers in a pre-competitive, industry-led study in subjects with schizophrenia and healthy volunteers.
Cecchi M, Adachi M, Basile A, Buhl DL, Chadchankar H, Christensen S, Christian E, Doherty J, Fadem KC, Farley B, Forman MS, Honda S, Johannesen J, Kinon BJ, Klamer D, Marino MJ, Missling C, O'Donnell P, Piser T, Puryear CB, Quirk MC, Rotte M, Sanchez C, Smith DG, Uslaner JM, Javitt DC, Keefe RSE, Mathalon D, Potter WZ, Walling DP, Ereshefsky L. Cecchi M, et al. Schizophr Res. 2023 Apr;254:178-189. doi: 10.1016/j.schres.2023.02.018. Epub 2023 Mar 13. Schizophr Res. 2023. PMID: 36921403 Free article.
RESULTS: Standardized ERP/EEG instrumentation and methods ensured few test failures. The automated data analysis pipeline allowed for near real-time analysis with no human intervention. Test-retest reliability was fair-to-excellent for most of the outcome measures. ...CONC …
RESULTS: Standardized ERP/EEG instrumentation and methods ensured few test failures. The automated data analysis pipeline allowed for near r …
Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice.
Anding A, Kinton S, Baranowski K, Brezzani A, De Busser H, Dufault MR, Finn P, Keefe K, Tetrault T, Li Y, Qiu W, Raes K, Vitse O, Zhang M, Ziegler R, Sardi SP, Hunter B, George K. Anding A, et al. J Pharmacol Exp Ther. 2023 Nov;387(2):188-203. doi: 10.1124/jpet.123.001593. Epub 2023 Sep 7. J Pharmacol Exp Ther. 2023. PMID: 37679046
Although miglustat increased the stability of both enzymes in fluorescent protein thermal shift assays and when incubated in neutral pH buffer over time, it reduced their enzymatic activity by 50%. Improvement in tissue glycogen clearance and transcriptional dysregulation …
Although miglustat increased the stability of both enzymes in fluorescent protein thermal shift assays and when incubated in neutral pH buff …
Impaired formation of stimulus-response, but not action-outcome, associations in rats with methamphetamine-induced neurotoxicity.
Son JH, Latimer C, Keefe KA. Son JH, et al. Neuropsychopharmacology. 2011 Nov;36(12):2441-51. doi: 10.1038/npp.2011.131. Epub 2011 Jul 20. Neuropsychopharmacology. 2011. PMID: 21775980 Free PMC article.
Methamphetamine (METH) induces neurotoxic changes, including partial striatal dopamine depletions, which are thought to contribute to cognitive dysfunction in rodents and humans. The dorsal striatum is implicated in action-outcome (A-O) and stimulus-response (S-R) a …
Methamphetamine (METH) induces neurotoxic changes, including partial striatal dopamine depletions, which are thought to contribute to cognit …
Psychology Internship Training Amidst COVID-19: Balancing Training Opportunities, Patient Care, and Risk of Exposure.
Stein MB, O'Keefe S, Mace R, Foley JD, White AE, Ruchensky JR, Curtiss J, Moran E, Evans C, Beck S. Stein MB, et al. J Clin Psychol Med Settings. 2023 Mar;30(1):61-71. doi: 10.1007/s10880-022-09890-9. Epub 2022 Jun 18. J Clin Psychol Med Settings. 2023. PMID: 35717453 Free PMC article.
The emergence of the 2019 novel coronavirus (COVID-19) has dramatically altered how psychologists deliver its training. At least for the time being, virtual care has become the primary method for delivering mental health services. ...We also surveyed multi-disciplinary sta …
The emergence of the 2019 novel coronavirus (COVID-19) has dramatically altered how psychologists deliver its training. At least for the …
Integrating Autism Care through a School-Based Intervention Model: A Pilot Study.
Dang K, Bent S, Lawton B, Warren T, Widjaja F, McDonald MG, Breard M, O'Keefe W, Hendren RL. Dang K, et al. J Clin Med. 2017 Oct 19;6(10):97. doi: 10.3390/jcm6100097. J Clin Med. 2017. PMID: 29048365 Free PMC article.

The TAPS showed a strong and statistically significant correlation, with improvement in aberrant behavior (r = -0.50; p = 0.008) and social responsiveness (r = -0.70; p < 0.001). The results also showed non-statistically significant improvements in aberrant behav

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The TAPS showed a strong and statistically significant correlation, with improvement in aberrant behavior (r = -0.50; p = 0.008) and …
Caffeine restores engagement speed but not shooting precision following 22 h of active wakefulness.
Tikuisis P, Keefe AA, McLellan TM, Kamimori G. Tikuisis P, et al. Aviat Space Environ Med. 2004 Sep;75(9):771-6. Aviat Space Environ Med. 2004. PMID: 15460628 Clinical Trial.
Subjects ingested 400, 100, and 100 mg of caffeine or placebo at 7.5, 3, and 0 h, respectively, prior to shooting. Measures of shooting performance included target engagement time (between target appearance and firing), friend-foe discrimination, accuracy, and precision. R …
Subjects ingested 400, 100, and 100 mg of caffeine or placebo at 7.5, 3, and 0 h, respectively, prior to shooting. Measures of shooting perf …