Challenges, progress, and opportunities: proceedings of the filovirus medical countermeasures workshop

Rona Hirschberg; Lucy A Ward; Nicole Kilgore; Rebecca Kurnat; Helen Schiltz; Mark T Albrecht; George W Christopher; Ed Nuzum

doi:10.3390/v6072673

Challenges, progress, and opportunities: proceedings of the filovirus medical countermeasures workshop

Viruses. 2014 Jul 9;6(7):2673-97. doi: 10.3390/v6072673.

Authors

Rona Hirschberg¹, Lucy A Ward², Nicole Kilgore³, Rebecca Kurnat⁴, Helen Schiltz⁵, Mark T Albrecht⁶, George W Christopher⁷, Ed Nuzum⁸

Affiliations

¹ Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Rona.Hirschberg@verizon.net.
² Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. lward@niaid.nih.gov.
³ Medical Countermeasure Systems, Department of Defense, Ft. Detrick, Frederick, MD 21702, USA. nicole.r.kilgore.civ@mail.mil.
⁴ Medical Countermeasure Systems, Department of Defense, Ft. Detrick, Frederick, MD 21702, USA. rebecca.kurnat.civ@mail.mil.
⁵ Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. hschiltz@niaid.nih.gov.
⁶ Biodefense Advanced Research and Development Authority, Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC 20201, USA. mark.albrecht@hhs.gov.
⁷ Medical Countermeasure Systems, Department of Defense, Fort Belvoir, VA 22060, USA. george.w.christopher.civ@mail.mil.
⁸ Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. enuzum@niaid.nih.gov.

Abstract

On August 22-23, 2013, agencies within the United States Department of Defense (DoD) and the Department of Health and Human Services (HHS) sponsored the Filovirus Medical Countermeasures (MCMs) Workshop as an extension of the activities of the Filovirus Animal Non-clinical Group (FANG). The FANG is a federally-recognized multi-Agency group established in 2011 to coordinate and facilitate U.S. government (USG) efforts to develop filovirus MCMs. The workshop brought together government, academic and industry experts to consider the needs for filovirus MCMs and evaluate the status of the product development pipeline. This report summarizes speaker presentations and highlights progress and challenges remaining in the field.

Publication types

Congress

MeSH terms

Animals
Antibodies, Neutralizing / administration & dosage
Antibodies, Viral / biosynthesis*
Filoviridae / immunology*
Filoviridae / pathogenicity
Filoviridae Infections / immunology
Filoviridae Infections / prevention & control*
Filoviridae Infections / virology
Guinea Pigs
Haplorhini
Humans
Immunity, Cellular / drug effects
Immunity, Humoral / drug effects
Mice
United States
United States Department of Defense
United States Dept. of Health and Human Services
Vaccines, DNA
Viral Vaccines / administration & dosage
Viral Vaccines / biosynthesis
Viral Vaccines / immunology*
Virus Replication / drug effects

Substances

Antibodies, Neutralizing
Antibodies, Viral
Vaccines, DNA
Viral Vaccines