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Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001.
Clin Cancer Res. 2001 Aug;7(8):2228-36.
Clin Cancer Res. 2001.
PMID: 11489796
Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells.
Barrett J, Birrer MJ, Kato GJ, Dosaka-Akita H, Dang CV.
Barrett J, et al.
Mol Cell Biol. 1992 Jul;12(7):3130-7. doi: 10.1128/mcb.12.7.3130-3137.1992.
Mol Cell Biol. 1992.
PMID: 1620120
Free PMC article.
However, L-Myc cotransforming activity was only 1 to 10% of that of c-Myc (M. J. Birrer, S. Segal, J. S. DeGreve, F. Kaye, E. A. Sausville, and J. D. Minna, Mol. Cell. Biol. 8:2668-2673, 1988). ...
However, L-Myc cotransforming activity was only 1 to 10% of that of c-Myc (M. J. Birrer, S. Segal, J. S. DeGreve, F. Kaye, E. A …
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