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Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists.
Bioorg Med Chem Lett. 2018 Feb 15;28(4):711-719. doi: 10.1016/j.bmcl.2018.01.014. Epub 2018 Jan 16.
Bioorg Med Chem Lett. 2018.
PMID: 29366653
Sustained Liver HBsAg Loss and Clonal T- and B-Cell Expansion upon Therapeutic DNA Vaccination Require Low HBsAg Levels.
Conceição-Neto N, Pierson W, Vacca M, Beyens M, De Clerck B, Aerts L, Voeten B, De Pooter D, Verschueren L, Dockx K, Vandenberk M, De Troyer E, Verwilt K, Van Hove C, Verslegers M, Bosseler L, Crabbe M, Krishna V, Nájera I, Van Gulck E.
Conceição-Neto N, et al. Among authors: de pooter d.
Vaccines (Basel). 2023 Dec 6;11(12):1825. doi: 10.3390/vaccines11121825.
Vaccines (Basel). 2023.
PMID: 38140229
Free PMC article.
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A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates.
De Pooter D, Van Gulck E, Chen A, Evans CF, Neefs JM, Horton H, Boden D.
De Pooter D, et al.
Vaccines (Basel). 2021 Aug 29;9(9):969. doi: 10.3390/vaccines9090969.
Vaccines (Basel). 2021.
PMID: 34579206
Free PMC article.
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2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.
Embrechts W, Herschke F, Pauwels F, Stoops B, Last S, Pieters S, Pande V, Pille G, Amssoms K, Smyej I, Dhuyvetter D, Scholliers A, Mostmans W, Van Dijck K, Van Schoubroeck B, Thone T, De Pooter D, Fanning G, Jonckers THM, Horton H, Raboisson P, McGowan D.
Embrechts W, et al. Among authors: de pooter d.
J Med Chem. 2018 Jul 26;61(14):6236-6246. doi: 10.1021/acs.jmedchem.8b00643. Epub 2018 Jul 17.
J Med Chem. 2018.
PMID: 29965759
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mRNA Therapeutic Vaccine for Hepatitis B Demonstrates Immunogenicity and Efficacy in the AAV-HBV Mouse Model.
De Pooter D, Pierson W, Pourshahian S, Dockx K, De Clerck B, Najera I, Davis H, Van Gulck E, Boden D.
De Pooter D, et al.
Vaccines (Basel). 2024 Feb 25;12(3):237. doi: 10.3390/vaccines12030237.
Vaccines (Basel). 2024.
PMID: 38543871
Free PMC article.
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Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus.
McGowan D, Herschke F, Pauwels F, Stoops B, Last S, Pieters S, Scholliers A, Thoné T, Van Schoubroeck B, De Pooter D, Mostmans W, Khamlichi MD, Embrechts W, Dhuyvetter D, Smyej I, Arnoult E, Demin S, Borghys H, Fanning G, Vlach J, Raboisson P.
McGowan D, et al. Among authors: de pooter d.
J Med Chem. 2016 Sep 8;59(17):7936-49. doi: 10.1021/acs.jmedchem.6b00747. Epub 2016 Aug 23.
J Med Chem. 2016.
PMID: 27513093
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Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.
McGowan DC, Herschke F, Pauwels F, Stoops B, Smyej I, Last S, Pieters S, Embrechts W, Khamlichi MD, Thoné T, Van Schoubroeck B, Mostmans W, Wuyts D, Verstappen D, Scholliers A, De Pooter D, Dhuyvetter D, Borghys H, Tuefferd M, Arnoult E, Hong J, Fanning G, Bollekens J, Urmaliya V, Teisman A, Horton H, Jonckers THM, Raboisson P.
McGowan DC, et al. Among authors: de pooter d.
J Med Chem. 2017 Jul 27;60(14):6137-6151. doi: 10.1021/acs.jmedchem.7b00365. Epub 2017 Jul 14.
J Med Chem. 2017.
PMID: 28671847
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