7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin

Ki Po Jang; Chan Hyuk Kim; Seong Wook Na; Dong Seok Jang; Hiyoung Kim; Heonjoong Kang; Eun Lee

doi:10.1016/j.bmcl.2010.02.037

7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2156-8. doi: 10.1016/j.bmcl.2010.02.037. Epub 2010 Feb 13.

Authors

Ki Po Jang¹, Chan Hyuk Kim, Seong Wook Na, Dong Seok Jang, Hiyoung Kim, Heonjoong Kang, Eun Lee

Affiliation

¹ Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Republic of Korea.

PMID: 20207542
DOI: 10.1016/j.bmcl.2010.02.037

Abstract

Carbonyl ylide cycloaddition strategy was employed in the synthesis of platensimycin analogs. 7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin are more potent analogs of platensimycin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adamantane / chemistry*
Adamantane / pharmacology*
Aminobenzoates / chemistry*
Aminobenzoates / pharmacology*
Anilides / chemistry*
Anilides / pharmacology*
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Enterococcus / drug effects
Gram-Positive Bacteria / drug effects*
Gram-Positive Bacterial Infections / drug therapy*
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects
Structure-Activity Relationship

Substances

Aminobenzoates
Anilides
Anti-Bacterial Agents
Adamantane
platensimycin