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The CaSR/TRPV4 coupling mediates pro-inflammatory macrophage function.
Chen X, Lu W, Lu C, Zhang L, Xu F, Dong H. Chen X, et al. Acta Physiol (Oxf). 2023 Apr;237(4):e13926. doi: 10.1111/apha.13926. Epub 2023 Jan 24. Acta Physiol (Oxf). 2023. PMID: 36606511
METHODS: The role of CaSR/TRPV4/Ca(2+) signaling was assessed in lipopolysaccharide (LPS)-treated peritoneal macrophages (PMs) from wild-type (WT) and TRPV4 knockout (TRPV4 KO) mice. The expression and function of CaSR and TRPV4 in PMs were analyzed by immunofluorescence a …
METHODS: The role of CaSR/TRPV4/Ca(2+) signaling was assessed in lipopolysaccharide (LPS)-treated peritoneal macrophages (PMs) from wild-typ …
Zinc pyrithione induces endothelium-dependent hyperpolarization-mediated mesenteric vasorelaxation in healthy and colitic mice.
Sun C, Zhang L, Zhang M, Wang J, Rong S, Lu W, Dong H. Sun C, et al. Biochem Pharmacol. 2023 Nov;217:115828. doi: 10.1016/j.bcp.2023.115828. Epub 2023 Sep 27. Biochem Pharmacol. 2023. PMID: 37774954
METHODS: The vasorelaxation of the second-order branch of the mesenteric artery from wide type (WT) mice, TRPV1(-/-)(KO) mice, and TRPV4(-/-)(KO) mice was determined using a Mulvany-style wire myograph. ...The ZPT/EDH-mediated vasorelaxation via TRPV1, TRPV4 and TRP …
METHODS: The vasorelaxation of the second-order branch of the mesenteric artery from wide type (WT) mice, TRPV1(-/-)(KO) mice, and TR …
Cl- induces endothelium-dependent mesenteric arteriolar vasorelaxation through the NKCC1/TRPV4/NCX axis.
Lu C, Zhang L, Chen X, Wan H, Dong H. Lu C, et al. Life Sci. 2023 Oct 1;330:121942. doi: 10.1016/j.lfs.2023.121942. Epub 2023 Jul 13. Life Sci. 2023. PMID: 37451399
KEY FINDINGS: The Cl(-) concentration-dependently induced vasorelaxation of mesenteric arteries likely through EDH. The Cl(-)-induced vasorelaxation was attenuated in TRPV4 KO mice and inhibited by selective blockers of Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) (bumetanide …
KEY FINDINGS: The Cl(-) concentration-dependently induced vasorelaxation of mesenteric arteries likely through EDH. The Cl(-)-induced vasore …
Beneficial effect of capsaicin via TRPV4/EDH signals on mesenteric arterioles of normal and colitis mice.
Zhang L, Lu W, Lu C, Guo Y, Chen X, Chen J, Xu F, Wan H, Dong H. Zhang L, et al. J Adv Res. 2022 Jul;39:291-303. doi: 10.1016/j.jare.2021.11.001. Epub 2021 Nov 7. J Adv Res. 2022. PMID: 35777913 Free PMC article.
METHODS: Vasorelaxation of human submucosal arterioles and the mesenteric arterioles from wide-type (WT) mice, TRPV1(-/-) and TRPV4(-/-) (KO) mice were measured. The expression and function of TRPV channels in endothelial cells were examined by q-PCR, immunostaining, Ca(2+ …
METHODS: Vasorelaxation of human submucosal arterioles and the mesenteric arterioles from wide-type (WT) mice, TRPV1(-/-) and TRPV4(-/-) ( …
Capsaicin inhibits intestinal Cl- secretion and promotes Na+ absorption by blocking TRPV4 channels in healthy and colitic mice.
Wan H, Chen XY, Zhang F, Chen J, Chu F, Sellers ZM, Xu F, Dong H. Wan H, et al. J Biol Chem. 2022 May;298(5):101847. doi: 10.1016/j.jbc.2022.101847. Epub 2022 Mar 18. J Biol Chem. 2022. PMID: 35314195 Free PMC article.
The short-circuit current (I(sc)) of the intestine from WT, TRPV1-, and TRPV4-KO mice were measured in Ussing chambers, and Ca(2+) imaging was performed on small intestinal epithelial cells. ...We found that capsaicin did not affect basal intestinal I(sc) but significantly …
The short-circuit current (I(sc)) of the intestine from WT, TRPV1-, and TRPV4-KO mice were measured in Ussing chambers, and Ca(2+) im …
The fractalkine/CX3CR1 system regulates β cell function and insulin secretion.
Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. Lee YS, et al. Cell. 2013 Apr 11;153(2):413-25. doi: 10.1016/j.cell.2013.03.001. Cell. 2013. PMID: 23582329 Free PMC article.
Here, we demonstrate that the fractalkine (FKN)/CX3CR1 system represents a regulatory mechanism for pancreatic islet beta cell function and insulin secretion. CX3CR1 knockout (KO) mice exhibited a marked defect in glucose and GLP1-stimulated insulin secretion, and this def …
Here, we demonstrate that the fractalkine (FKN)/CX3CR1 system represents a regulatory mechanism for pancreatic islet beta cell function and …
Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3(-) secretion via a novel GC-C- and CFTR-independent pathway.
Sellers ZM, Mann E, Smith A, Ko KH, Giannella R, Cohen MB, Barrett KE, Dong H. Sellers ZM, et al. FASEB J. 2008 May;22(5):1306-16. doi: 10.1096/fj.06-7540com. Epub 2007 Dec 20. FASEB J. 2008. PMID: 18096816
The aims of this study were to determine whether a non-GC-C receptor exists for STa and what is the functional relevance of this for intestinal bicarbonate secretion in mice. (125)I-STa-binding experiments were performed with intestinal mucosae from GC-C knockout (KO) and …
The aims of this study were to determine whether a non-GC-C receptor exists for STa and what is the functional relevance of this for intesti …