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DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζ.
Pramio DT, Vieceli FM, Varella-Branco E, Goes CP, Kobayashi GS, da Silva Pelegrina DV, de Moraes BC, El Allam A, De Kumar B, Jara G, Farfel JM, Bennett DA, Kundu S, Viapiano MS, Reis EM, de Oliveira PSL, Dos Santos E Passos-Bueno MR, Rothlin CV, Ghosh S, Schechtman D. Pramio DT, et al. Biochim Biophys Acta Gene Regul Mech. 2023 Mar;1866(1):194909. doi: 10.1016/j.bbagrm.2023.194909. Epub 2023 Jan 20. Biochim Biophys Acta Gene Regul Mech. 2023. PMID: 36682583 Free PMC article.
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target.
Moraes BC, Ribeiro-Filho HV, Roldão AP, Toniolo EF, Carretero GPB, Sgro GG, Batista FAH, Berardi DE, Oliveira VRS, Tomasin R, Vieceli FM, Pramio DT, Cardoso AB, Figueira ACM, Farah SC, Devi LA, Dale CS, de Oliveira PSL, Schechtman D. Moraes BC, et al. Among authors: pramio dt. Sci Signal. 2022 Apr 26;15(731):eabm6046. doi: 10.1126/scisignal.abm6046. Epub 2022 Apr 26. Sci Signal. 2022. PMID: 35471943