Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells.
Hewitson JP, West KA, James KR, Rani GF, Dey N, Romano A, Brown N, Teichmann SA, Kaye PM, Lagos D.
Hewitson JP, et al.
J Immunol. 2020 Jun 1;204(11):2949-2960. doi: 10.4049/jimmunol.1900940. Epub 2020 Apr 22.
J Immunol. 2020.
PMID: 32321759
Free PMC article.
Among those, we show that suppression of Malat1 is a hallmark of CD4(+) T cell activation, but its complete deletion results in more potent immune responses to infection. This is because Malat1(-/-) Th1 and Th2 cells express lower levels of the immunosuppressive cytokine I …
Among those, we show that suppression of Malat1 is a hallmark of CD4(+) T cell activation, but its complete deletion results in more …