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Long Non-Coding RNA Function in CD4(+) T Cells: What We Know and What Next?
West KA, Lagos D. West KA, et al. Noncoding RNA. 2019 Jul 12;5(3):43. doi: 10.3390/ncrna5030043. Noncoding RNA. 2019. PMID: 31336952 Free PMC article. Review.
Research into long non-coding RNAs (lncRNAs) has gathered speed in recent years, and a growing body of evidence has implicated lncRNAs in a vast range of cellular functions including gene regulation, chromosome organisation and splicing. T helper cells offer an ideal platf …
Research into long non-coding RNAs (lncRNAs) has gathered speed in recent years, and a growing body of evidence has implicated lncRNAs in a …
miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity.
Hewitson JP, Shah KM, Brown N, Grevitt P, Hain S, Newling K, Sharp TV, Kaye PM, Lagos D. Hewitson JP, et al. EMBO Rep. 2019 Apr;20(4):e46620. doi: 10.15252/embr.201846620. Epub 2019 Mar 4. EMBO Rep. 2019. PMID: 30833344 Free PMC article.
Determining the mechanisms that distinguish protective immunity from pathological chronic inflammation remains a fundamental challenge. miR-132 has been shown to play largely immunoregulatory roles in immunity; however, its role in CD4(+) T cell function is poorly understo …
Determining the mechanisms that distinguish protective immunity from pathological chronic inflammation remains a fundamental challenge. miR- …
Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells.
Hewitson JP, West KA, James KR, Rani GF, Dey N, Romano A, Brown N, Teichmann SA, Kaye PM, Lagos D. Hewitson JP, et al. J Immunol. 2020 Jun 1;204(11):2949-2960. doi: 10.4049/jimmunol.1900940. Epub 2020 Apr 22. J Immunol. 2020. PMID: 32321759 Free PMC article.
Among those, we show that suppression of Malat1 is a hallmark of CD4(+) T cell activation, but its complete deletion results in more potent immune responses to infection. This is because Malat1(-/-) Th1 and Th2 cells express lower levels of the immunosuppressive cytokine I …
Among those, we show that suppression of Malat1 is a hallmark of CD4(+) T cell activation, but its complete deletion results in more …
MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells.
Yee D, Shah KM, Coles MC, Sharp TV, Lagos D. Yee D, et al. J Biol Chem. 2017 Dec 15;292(50):20683-20693. doi: 10.1074/jbc.M117.809053. Epub 2017 Oct 24. J Biol Chem. 2017. PMID: 29066622 Free PMC article.
Programmed death ligand-1 (PD-L1) is a critical regulator of T cell function contributing to peripheral immune tolerance. Although it has been shown that posttranscriptional regulatory mechanisms control PD-L1 expression in cancer, it remains unknown whether such regulator …
Programmed death ligand-1 (PD-L1) is a critical regulator of T cell function contributing to peripheral immune tolerance. Although it …