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Page 1
Small-molecule modulators of tumor necrosis factor signaling.
Chédotal H, Narayanan D, Povlsen K, Gotfredsen CH, Brambilla R, Gajhede M, Bach A, Clausen MH. Chédotal H, et al. Among authors: narayanan d. Drug Discov Today. 2023 Jun;28(6):103575. doi: 10.1016/j.drudis.2023.103575. Epub 2023 Mar 30. Drug Discov Today. 2023. PMID: 37003513 Free article. Review.
Targeting the Redox Landscape in Cancer Therapy.
Narayanan D, Ma S, Özcelik D. Narayanan D, et al. Cancers (Basel). 2020 Jun 27;12(7):1706. doi: 10.3390/cancers12071706. Cancers (Basel). 2020. PMID: 32605023 Free PMC article. Review.
Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.
Zang J, Peters F, Cambet Y, Cifuentes-Pagano E, Hissabu MMS, Dustin CM, Svensson LH, Olesen MM, Poulsen MFL, Jacobsen S, Tuelung PS, Narayanan D, Langkilde AE, Gajhede M, Pagano PJ, Jaquet V, Vilhardt F, Bach A. Zang J, et al. Among authors: narayanan d. J Med Chem. 2023 Nov 9;66(21):14963-15005. doi: 10.1021/acs.jmedchem.3c01548. Epub 2023 Oct 19. J Med Chem. 2023. PMID: 37857466
Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
Narayanan D, Tran KT, Pallesen JS, Solbak SMØ, Qin Y, Mukminova E, Luchini M, Vasilyeva KO, González Chichón D, Goutsiou G, Poulsen C, Haapanen N, Popowicz GM, Sattler M, Olagnier D, Gajhede M, Bach A. Narayanan D, et al. J Med Chem. 2022 Nov 10;65(21):14481-14526. doi: 10.1021/acs.jmedchem.2c00830. Epub 2022 Oct 20. J Med Chem. 2022. PMID: 36263945
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Pallesen JS, Narayanan D, Tran KT, Solbak SMØ, Marseglia G, Sørensen LME, Høj LJ, Munafò F, Carmona RMC, Garcia AD, Desu HL, Brambilla R, Johansen TN, Popowicz GM, Sattler M, Gajhede M, Bach A. Pallesen JS, et al. Among authors: narayanan d. J Med Chem. 2021 Apr 22;64(8):4623-4661. doi: 10.1021/acs.jmedchem.0c02094. Epub 2021 Apr 5. J Med Chem. 2021. PMID: 33818106 Free article.
A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
Tran KT, Pallesen JS, Solbak SMØ, Narayanan D, Baig A, Zang J, Aguayo-Orozco A, Carmona RMC, Garcia AD, Bach A. Tran KT, et al. Among authors: narayanan d. J Med Chem. 2019 Sep 12;62(17):8028-8052. doi: 10.1021/acs.jmedchem.9b00723. Epub 2019 Aug 27. J Med Chem. 2019. PMID: 31411465 Free article.