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A metabolite attenuates neuroinflammation, synaptic loss and cognitive deficits induced by chronic infection of Toxoplasma gondii.
He Y, Xu D, Yan Z, Wu Y, Zhang Y, Tian X, Zhu J, Liu Z, Cheng W, Zheng K, Yang X, Yu Y, Pan W. He Y, et al. Front Immunol. 2022 Dec 22;13:1043572. doi: 10.3389/fimmu.2022.1043572. eCollection 2022. Front Immunol. 2022. PMID: 36618398 Free PMC article.
To our attention, the infection robustly upregulated the expression of genes associated with pro-inflammatory responses, which was characterized by microglia activation and disorder of Acod1/itaconate axis. Interestingly, administration of dimethyl itaconate (DI, an …
To our attention, the infection robustly upregulated the expression of genes associated with pro-inflammatory responses, which was character …