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Short-term mechanical circulatory support (intra-aortic balloon pump, Impella, extracorporeal membrane oxygenation, TandemHeart): a review.
Wong ASK, Sin SWC. Wong ASK, et al. Ann Transl Med. 2020 Jul;8(13):829. doi: 10.21037/atm-20-2171. Ann Transl Med. 2020. PMID: 32793674 Free PMC article. Review.
Premature initiation of mechanical circulatory support exposes the patient to unnecessary risk, whereas delaying therapy leads to irreversible end-organ injury, rendering any intervention medically futile. Cannulation methods, pump designs, and circuit configurations diffe …
Premature initiation of mechanical circulatory support exposes the patient to unnecessary risk, whereas delaying therapy leads to irreversib …
Our continuing exploration of medically unexplained symptoms.
Mauksch LB, Fogarty CT. Mauksch LB, et al. Fam Syst Health. 2016 Dec;34(4):305-308. doi: 10.1037/fsh0000244. Fam Syst Health. 2016. PMID: 27977288
In the first article, Gates, Petterson, Wingrove, Miller, and Klink (2016) examined 110,000 office visits to primary care providers between 2002 and 2010. In the second article, Clarke (2016), an internist and gastroenterologist, presents a model for diagnosing and treatin …
In the first article, Gates, Petterson, Wingrove, Miller, and Klink (2016) examined 110,000 office visits to primary care providers b …
Challenges, opportunities, and innovative statistical designs for precision oncology trials.
Yin J, Shen S, Shi Q. Yin J, et al. Ann Transl Med. 2022 Sep;10(18):1038. doi: 10.21037/atm-22-356. Ann Transl Med. 2022. PMID: 36267789 Free PMC article. Review.
The shift to the molecular view of cancer leads to increasingly small cancer populations for clinical trials which may be underpowered using traditional statistical designs. This paradigm shift lead to the recent developments of innovative clinical trial designs to …
The shift to the molecular view of cancer leads to increasingly small cancer populations for clinical trials which may be underpowered using …
Minimally invasive ventricular assist device implantation.
Al-Naamani A, Fahr F, Khan A, Bireta C, Nozdrzykowski M, Feder S, Deshmukh N, Jubeh M, Eifert S, Jawad K, Schulz U, Borger MA, Saeed D. Al-Naamani A, et al. J Thorac Dis. 2021 Mar;13(3):2010-2017. doi: 10.21037/jtd-20-1492. J Thorac Dis. 2021. PMID: 33841987 Free PMC article. Review.
Left ventricular assist devices (LVADs) are traditionally implanted through median sternotomy (MS). However, improvement in the pump designs during the last years led to evolvement of new surgical approaches that aim to reduce the invasiveness of the procedure. ...
Left ventricular assist devices (LVADs) are traditionally implanted through median sternotomy (MS). However, improvement in the pump desi …
Developments in targeted therapy & immunotherapy-how non-small cell lung cancer management will change in the next decade: a narrative review.
Li MSC, Mok KKS, Mok TSK. Li MSC, et al. Ann Transl Med. 2023 Aug 30;11(10):358. doi: 10.21037/atm-22-4444. Epub 2023 Mar 23. Ann Transl Med. 2023. PMID: 37675321 Free PMC article. Review.
Development of targeted therapies in advanced lung cancer is driven by advanced genomic sequencing techniques, better understanding of drug resistance mechanisms, and improved drug designs. The list of targetable molecular alteration is continuously expanding, and next gen …
Development of targeted therapies in advanced lung cancer is driven by advanced genomic sequencing techniques, better understanding of drug …
The future of penile prostheses for the treatment of erectile dysfunction.
Lindsey JP 2nd, Lue TF, Shindel AW. Lindsey JP 2nd, et al. Transl Androl Urol. 2020 Mar;9(Suppl 2):S244-S251. doi: 10.21037/tau.2019.09.01. Transl Androl Urol. 2020. PMID: 32257865 Free PMC article.
We include recommendations on future technical innovations, post-operative management, and novel implant designs that may revolutionize the future management of ED....
We include recommendations on future technical innovations, post-operative management, and novel implant designs that may revolutioni …
Advancing Clinical Trials to Streamline Drug Development.
Bates SE, Berry DA, Balasubramaniam S, Bailey S, LoRusso PM, Rubin EH. Bates SE, et al. Clin Cancer Res. 2015 Oct 15;21(20):4527-35. doi: 10.1158/1078-0432.CCR-15-0039. Clin Cancer Res. 2015. PMID: 26473188 Free PMC article.
Recognizing the need for new approaches, industry, investigators, and regulators have responded to this challenge. New clinical trial designs are being evaluated to incorporate the genomic sequence data being obtained almost routinely after cancer diagnosis. ...
Recognizing the need for new approaches, industry, investigators, and regulators have responded to this challenge. New clinical trial des …
Enhancing diversity of clinical trial populations in multiple sclerosis.
Marrie RA, Chataway J, Bierer BE, Finlayson M, Martinez-Lapiscina EH, Panagoulias J, Sormani MP, Williams MJ, Amezcua L. Marrie RA, et al. Mult Scler. 2023 Aug;29(9):1174-1185. doi: 10.1177/13524585231189677. Mult Scler. 2023. PMID: 37555490 Free PMC article. Review.
RESULTS: Recommendations include use of diversity plans, community engagement and education, cultural competency training, biologically justified rather than templated eligibility criteria, adaptive designs that allow broadening of eligibility criteria over the course of a …
RESULTS: Recommendations include use of diversity plans, community engagement and education, cultural competency training, biologically just …
Absorptive capacity in the adoption of innovations in health: a scoping review.
Godfrey CM, Kircher C, Ashoor HM, Ross-White A, Glandon L, Wilson R, McSharry J, Tricco AC, Zitzelsberger L, Kaan D, Sears K. Godfrey CM, et al. JBI Evid Synth. 2023 Jan 1;21(1):6-32. doi: 10.11124/JBIES-21-00436. JBI Evid Synth. 2023. PMID: 35942617 Review.
INCLUSION CRITERIA: This scoping review included published and unpublished primary studies (ie, experimental, quasi-experimental, observational, and qualitative study designs), as well as reviews that broadly focused on the adoption of innovations at the organizational lev …
INCLUSION CRITERIA: This scoping review included published and unpublished primary studies (ie, experimental, quasi-experimental, observatio …
43 results