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The following term was not found in PubMed: Jin-Uk
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Prediction of rodent carcinogenicity using the DEREK system for 30 chemicals currently being tested by the National Toxicology Program. The DEREK Collaborative Group.
Marchant CA. Marchant CA. Environ Health Perspect. 1996 Oct;104 Suppl 5(Suppl 5):1065-73. doi: 10.1289/ehp.96104s51065. Environ Health Perspect. 1996. PMID: 8933056 Free PMC article.
DEREK is a knowledge-based expert system for the qualitative prediction of toxicity. ...This process has led to the proposal of a number of improvements to the DEREK carcinogenicity knowledge base....
DEREK is a knowledge-based expert system for the qualitative prediction of toxicity. ...This process has led to the proposal of a num …
Computer prediction of possible toxic action from chemical structure: an update on the DEREK system.
Ridings JE, Barratt MD, Cary R, Earnshaw CG, Eggington CE, Ellis MK, Judson PN, Langowski JJ, Marchant CA, Payne MP, Watson WP, Yih TD. Ridings JE, et al. Toxicology. 1996 Jan 8;106(1-3):267-79. doi: 10.1016/0300-483x(95)03190-q. Toxicology. 1996. PMID: 8571398
Major developments of the DEREK program and knowledge-base have taken place in the last 3 years. ...In addition to the continued expansion of the knowledge-base, a number of enhancements are planned in the DEREK program. In particular, work is in progress to develop …
Major developments of the DEREK program and knowledge-base have taken place in the last 3 years. ...In addition to the continued expa …
Knowledge-based expert systems for toxicity and metabolism prediction: DEREK, StAR and METEOR.
Greene N, Judson PN, Langowski JJ, Marchant CA. Greene N, et al. SAR QSAR Environ Res. 1999;10(2-3):299-314. doi: 10.1080/10629369908039182. SAR QSAR Environ Res. 1999. PMID: 10491855
LHASA Limited has been developing knowledge-based expert systems for toxicity and metabolism prediction in collaboration with industry and regulatory authorities. These systems, DEREK, StAR and METEOR, use rules to describe the relationship between chemical structure and e …
LHASA Limited has been developing knowledge-based expert systems for toxicity and metabolism prediction in collaboration with industry and r …
Structure-activity relationships for skin sensitization: recent improvements to Derek for Windows.
Langton K, Patlewicz GY, Long A, Marchant CA, Basketter DA. Langton K, et al. Contact Dermatitis. 2006 Dec;55(6):342-7. doi: 10.1111/j.1600-0536.2006.00969.x. Contact Dermatitis. 2006. PMID: 17101009
Derek for Windows (DfW) is a knowledge-based expert system that predicts the toxicity of a chemical from its structure. ...
Derek for Windows (DfW) is a knowledge-based expert system that predicts the toxicity of a chemical from its structure. ...
Using argumentation for absolute reasoning about the potential toxicity of chemicals.
Judson PN, Marchant CA, Vessey JD. Judson PN, et al. J Chem Inf Comput Sci. 2003 Sep-Oct;43(5):1364-70. doi: 10.1021/ci020272g. J Chem Inf Comput Sci. 2003. PMID: 14502468
The application of a new argumentation model is illustrated by reference to DEREK for Windows, a knowledge-based expert system for the prediction of the toxicity of chemicals. ...
The application of a new argumentation model is illustrated by reference to DEREK for Windows, a knowledge-based expert system for th …
Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents.
Matthews EJ, Kruhlak NL, Benz RD, Contrera JF, Marchant CA, Yang C. Matthews EJ, et al. Toxicol Mech Methods. 2008;18(2-3):189-206. doi: 10.1080/15376510701857379. Toxicol Mech Methods. 2008. PMID: 20020914
Specific examples are provided to demonstrate that consensus-positive predictions of carcinogenicity by two QSAR programs identified both genotoxic and nongenotoxic carcinogens and that they detected 98.7% of the carcinogens linked in this study to Derek for Windows define …
Specific examples are provided to demonstrate that consensus-positive predictions of carcinogenicity by two QSAR programs identified both ge …
In silico tools for sharing data and knowledge on toxicity and metabolism: derek for windows, meteor, and vitic.
Marchant CA, Briggs KA, Long A. Marchant CA, et al. Toxicol Mech Methods. 2008;18(2-3):177-87. doi: 10.1080/15376510701857320. Toxicol Mech Methods. 2008. PMID: 20020913
ABSTRACT Lhasa Limited is a not-for-profit organization that exists to promote the sharing of data and knowledge in chemistry and the life sciences. It has developed the software tools Derek for Windows, Meteor, and Vitic to facilitate such sharing. Derek for Window …
ABSTRACT Lhasa Limited is a not-for-profit organization that exists to promote the sharing of data and knowledge in chemistry and the life s …
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part C: use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities.
Matthews EJ, Kruhlak NL, Benz RD, Aragonés Sabaté D, Marchant CA, Contrera JF. Matthews EJ, et al. Regul Toxicol Pharmacol. 2009 Jun;54(1):43-65. doi: 10.1016/j.yrtph.2009.01.007. Regul Toxicol Pharmacol. 2009. PMID: 19422100
BioEpisteme QSAR software was used to predict possible molecular targets of drug molecules and Derek for Windows expert system software to predict chemical structural alerts and plausible MOAs for the AEs. ...
BioEpisteme QSAR software was used to predict possible molecular targets of drug molecules and Derek for Windows expert system softwa …