Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

Luminiţa Măruţescu; Larisa Calu; Mariana Carmen Chifiriuc; Coralia Bleotu; Constantin-Gabriel Daniliuc; Denisa Fălcescu; Crina Maria Kamerzan; Mihaela Badea; Rodica Olar

doi:10.3390/molecules22071233

Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

Molecules. 2017 Jul 22;22(7):1233. doi: 10.3390/molecules22071233.

Authors

Affiliations

¹ Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor Str., 60101 Bucharest, Romania. lumi.marutescu@gmail.com.
² Environment and Earth Sciences Department, Research Institute of the University of Bucharest-ICUB, Life, Spl. Independentei 91-95, 010271 Bucharest, Romania. lumi.marutescu@gmail.com.
³ Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, Romania. carmen_balotescu@yahoo.com.
⁴ Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor Str., 60101 Bucharest, Romania. crina.saviuc@yahoo.com.
⁵ Environment and Earth Sciences Department, Research Institute of the University of Bucharest-ICUB, Life, Spl. Independentei 91-95, 010271 Bucharest, Romania. crina.saviuc@yahoo.com.
⁶ Stefan S Nicolau Institute of Virology, 285 Mihai Bravu Ave., 030304 Bucharest, Romania. larisa.calu@yahoo.com.
⁷ Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany. denisa_ktalina_89@yahoo.com.
⁸ Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, Romania. cbleotu@yahoo.com.
⁹ Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor Str., 60101 Bucharest, Romania. constantin.daniliuc@uni-muenster.de.
¹⁰ Environment and Earth Sciences Department, Research Institute of the University of Bucharest-ICUB, Life, Spl. Independentei 91-95, 010271 Bucharest, Romania. constantin.daniliuc@uni-muenster.de.
¹¹ Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, Romania. mihaela.badea@chimie.unibuc.ro.
¹² Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, Romania. rodica.olar@chimie.unibuc.ro.

Abstract

Three complexes, namely [Co(dmtp)₂(OH₂)₄][CoCl₄] (1), [Co(dmtp)₂Cl₂] (2) and [Co(dmtp)₂(OH₂)₄]Cl₂∙2H₂O (3) (dmtp: 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine), were synthesized and characterized by spectral (IR, UV-Vis-NIR), and magnetic measurements at room temperature, as well as single crystal X-ray diffraction. Complex (1) crystallizes in monoclinic system (space group C2/c), complex (2) adopts an orthorhombic system (space group Pbca), and complex (3) crystallizes in triclinic system (space group P1). Various types of extended hydrogen bonds and π-π interactions provide a supramolecular architecture for all complexes. All species were evaluated for antimicrobial activity towards planktonic and biofilm-embedded microbial cells and influence on HEp-2 cell viability, cellular cycle and gene expression.

Keywords: 1,2,4-triazolo[1,5-a]pyrimidine; Co(II) complex; biofilm; cis-disposition; cytotoxicity.

MeSH terms

Anti-Infective Agents / adverse effects
Anti-Infective Agents / chemistry*
Anti-Infective Agents / pharmacology*
Cell Line
Cell Survival / drug effects
Crystallography, X-Ray
Humans
Hydrogen Bonding
Microbial Sensitivity Tests
Molecular Structure
Pyrimidines / chemistry*
X-Ray Diffraction

Substances

Anti-Infective Agents
Pyrimidines
pyrimidine