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2002 1
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Page 1
C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.
Papahatjis DP, Nahmias VR, Nikas SP, Andreou T, Alapafuja SO, Tsotinis A, Guo J, Fan P, Makriyannis A. Papahatjis DP, et al. J Med Chem. 2007 Aug 23;50(17):4048-60. doi: 10.1021/jm070121a. Epub 2007 Aug 2. J Med Chem. 2007. PMID: 17672444
( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.
Liu Y, Ji L, Eno M, Kudalkar S, Li AL, Schimpgen M, Benchama O, Morales P, Xu S, Hurst D, Wu S, Mohammad KA, Wood JT, Zvonok N, Papahatjis DP, Zhou H, Honrao C, Mackie K, Reggio P, Hohmann AG, Marnett LJ, Makriyannis A, Nikas SP. Liu Y, et al. Among authors: papahatjis dp. J Med Chem. 2018 Oct 11;61(19):8639-8657. doi: 10.1021/acs.jmedchem.8b00611. Epub 2018 Sep 21. J Med Chem. 2018. PMID: 30196704
Novel 1',1'-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist.
Nikas SP, Alapafuja SO, Papanastasiou I, Paronis CA, Shukla VG, Papahatjis DP, Bowman AL, Halikhedkar A, Han X, Makriyannis A. Nikas SP, et al. Among authors: papahatjis dp. J Med Chem. 2010 Oct 14;53(19):6996-7010. doi: 10.1021/jm100641g. J Med Chem. 2010. PMID: 20925434 Free PMC article.
The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model.
Nikas SP, Grzybowska J, Papahatjis DP, Charalambous A, Banijamali AR, Chari R, Fan P, Kourouli T, Lin S, Nitowski AJ, Marciniak G, Guo Y, Li X, Wang CL, Makriyannis A. Nikas SP, et al. Among authors: papahatjis dp. AAPS J. 2004 Oct 19;6(4):e30. doi: 10.1208/aapsj060430. AAPS J. 2004. PMID: 15760095 Free PMC article.
16 results