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2009 1
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Page 1
The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells.
El Haddad N, Moore R, Heathcote D, Mounayar M, Azzi J, Mfarrej B, Batal I, Ting C, Atkinson M, Sayegh MH, Ashton-Rickardt PG, Abdi R. El Haddad N, et al. Among authors: heathcote d. J Immunol. 2011 Sep 1;187(5):2252-60. doi: 10.4049/jimmunol.1003981. Epub 2011 Jul 27. J Immunol. 2011. PMID: 21795594
RETRACTED: T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration.
Okoye I, Wang L, Pallmer K, Richter K, Ichimura T, Haas R, Crouse J, Choi O, Heathcote D, Lovo E, Mauro C, Abdi R, Oxenius A, Rutschmann S, Ashton-Rickardt PG. Okoye I, et al. Among authors: heathcote d. Science. 2015 May 29;348(6238):995-1001. doi: 10.1126/science.aaa7516. Epub 2015 Apr 16. Science. 2015. PMID: 25883318 Free article. Retracted.
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.
Ali S, Heathcote DA, Kroll SH, Jogalekar AS, Scheiper B, Patel H, Brackow J, Siwicka A, Fuchter MJ, Periyasamy M, Tolhurst RS, Kanneganti SK, Snyder JP, Liotta DC, Aboagye EO, Barrett AG, Coombes RC. Ali S, et al. Among authors: heathcote da. Cancer Res. 2009 Aug 1;69(15):6208-15. doi: 10.1158/0008-5472.CAN-09-0301. Epub 2009 Jul 28. Cancer Res. 2009. PMID: 19638587 Free PMC article.
Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells.
Azzi J, Skartsis N, Mounayar M, Magee CN, Batal I, Ting C, Moore R, Riella LV, Ohori S, Abdoli R, Smith B, Fiorina P, Heathcote D, Bakhos T, Ashton-Rickardt PG, Abdi R. Azzi J, et al. Among authors: heathcote d. J Immunol. 2013 Sep 1;191(5):2319-27. doi: 10.4049/jimmunol.1300851. Epub 2013 Aug 2. J Immunol. 2013. PMID: 23913965 Free PMC article.
A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
Heathcote DA, Patel H, Kroll SH, Hazel P, Periyasamy M, Alikian M, Kanneganti SK, Jogalekar AS, Scheiper B, Barbazanges M, Blum A, Brackow J, Siwicka A, Pace RD, Fuchter MJ, Snyder JP, Liotta DC, Freemont PS, Aboagye EO, Coombes RC, Barrett AG, Ali S. Heathcote DA, et al. J Med Chem. 2010 Dec 23;53(24):8508-22. doi: 10.1021/jm100732t. Epub 2010 Nov 16. J Med Chem. 2010. PMID: 21080703