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A single intranasal administration of AdCOVID protects against SARS-CoV-2 infection in the upper and lower respiratory tracts.
Schultz MD, Suschak JJ, Botta D, Silva-Sanchez A, King RG, Detchemendy TW, Meshram CD, Foote JB, Zhou F, Tipper JL, Zhang J, Harrod KS, Leal SM Jr, Randall TD, Roberts MS, Georges B, Lund FE. Schultz MD, et al. Among authors: botta d. Hum Vaccin Immunother. 2022 Nov 30;18(6):2127292. doi: 10.1080/21645515.2022.2127292. Epub 2022 Oct 4. Hum Vaccin Immunother. 2022. PMID: 36194255 Free PMC article.
Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice.
King RG, Silva-Sanchez A, Peel JN, Botta D, Meza-Perez S, Allie R, Schultz MD, Liu M, Bradley JE, Qiu S, Yang G, Zhou F, Zumaquero E, Simpler TS, Mousseau B, Killian JT, Dean B, Shang Q, Tipper JL, Risley C, Harrod KS, Feng R, Lee Y, Shiberu B, Krishnan V, Peguillet I, Zhang J, Green T, Randall TD, Georges B, Lund FE, Roberts S. King RG, et al. Among authors: botta d. bioRxiv [Preprint]. 2020 Oct 11:2020.10.10.331348. doi: 10.1101/2020.10.10.331348. bioRxiv. 2020. PMID: 33052351 Free PMC article. Updated. Preprint.
IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation.
Zumaquero E, Stone SL, Scharer CD, Jenks SA, Nellore A, Mousseau B, Rosal-Vela A, Botta D, Bradley JE, Wojciechowski W, Ptacek T, Danila MI, Edberg JC, Bridges SL Jr, Kimberly RP, Chatham WW, Schoeb TR, Rosenberg AF, Boss JM, Sanz I, Lund FE. Zumaquero E, et al. Among authors: botta d. Elife. 2019 May 15;8:e41641. doi: 10.7554/eLife.41641. Elife. 2019. PMID: 31090539 Free PMC article.
Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge.
King RG, Silva-Sanchez A, Peel JN, Botta D, Dickson AM, Pinto AK, Meza-Perez S, Allie SR, Schultz MD, Liu M, Bradley JE, Qiu S, Yang G, Zhou F, Zumaquero E, Simpler TS, Mousseau B, Killian JT Jr, Dean B, Shang Q, Tipper JL, Risley CA, Harrod KS, Feng T, Lee Y, Shiberu B, Krishnan V, Peguillet I, Zhang J, Green TJ, Randall TD, Suschak JJ, Georges B, Brien JD, Lund FE, Roberts MS. King RG, et al. Among authors: botta d. Vaccines (Basel). 2021 Aug 9;9(8):881. doi: 10.3390/vaccines9080881. Vaccines (Basel). 2021. PMID: 34452006 Free PMC article.
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