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1977 1
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1986 2
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2008 3
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49 results

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Page 1
Stem Cell Therapy in Heart Diseases - Cell Types, Mechanisms and Improvement Strategies.
Müller P, Lemcke H, David R. Müller P, et al. Among authors: david r. Cell Physiol Biochem. 2018;48(6):2607-2655. doi: 10.1159/000492704. Epub 2018 Aug 17. Cell Physiol Biochem. 2018. PMID: 30121644 Free article. Review.
Since the first transplantation into human patients, several stem cell types have been applied in this field, including bone marrow derived stem cells, cardiac progenitors as well as embryonic stem cells and their derivatives. ...
Since the first transplantation into human patients, several stem cell types have been applied in this field, including bone marro …
Image-guided radiotherapy and -brachytherapy for cervical cancer.
Dutta S, Nguyen NP, Vock J, Kerr C, Godinez J, Bose S, Jang S, Chi A, Almeida F, Woods W, Desai A, David R, Karlsson UL, Altdorfer G; International Geriatric Radiotherapy Group. Dutta S, et al. Among authors: david r. Front Oncol. 2015 Mar 17;5:64. doi: 10.3389/fonc.2015.00064. eCollection 2015. Front Oncol. 2015. PMID: 25853092 Free PMC article. Review.
Image-guided radiotherapy (IGRT) may decrease treatment toxicity of whole pelvic radiation because of its potential for bone marrow, bowel, and bladder sparring. Tumor shrinkage during whole pelvic IGRT may optimize image-guided brachytherapy (IGBT), allowing for be …
Image-guided radiotherapy (IGRT) may decrease treatment toxicity of whole pelvic radiation because of its potential for bone marro …
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology.
Chou DB, Frismantas V, Milton Y, David R, Pop-Damkov P, Ferguson D, MacDonald A, Vargel Bölükbaşı Ö, Joyce CE, Moreira Teixeira LS, Rech A, Jiang A, Calamari E, Jalili-Firoozinezhad S, Furlong BA, O'Sullivan LR, Ng CF, Choe Y, Marquez S, Myers KC, Weinberg OK, Hasserjian RP, Novak R, Levy O, Prantil-Baun R, Novina CD, Shimamura A, Ewart L, Ingber DE. Chou DB, et al. Among authors: david r. Nat Biomed Eng. 2020 Apr;4(4):394-406. doi: 10.1038/s41551-019-0495-z. Epub 2020 Jan 27. Nat Biomed Eng. 2020. PMID: 31988457 Free PMC article.
The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology under myelotoxic stress induced by drugs, radiation or genetic mutations. ...
The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology under myelotoxic stress induced by dru …
RNA-Based Strategies for Cardiac Reprogramming of Human Mesenchymal Stromal Cells.
Mueller P, Wolfien M, Ekat K, Lang CI, Koczan D, Wolkenhauer O, Hahn O, Peters K, Lang H, David R, Lemcke H. Mueller P, et al. Among authors: david r. Cells. 2020 Feb 22;9(2):504. doi: 10.3390/cells9020504. Cells. 2020. PMID: 32098400 Free PMC article.
Here we used non-integrative methods, including microRNA and mRNA, for cardiac reprogramming of adult MSC derived from bone marrow, dental follicle, and adipose tissue. We found that MSC derived from adipose tissue can partly be reprogrammed into the cardiac lineage …
Here we used non-integrative methods, including microRNA and mRNA, for cardiac reprogramming of adult MSC derived from bone marrow …
Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors.
Chou DB, Furlong BA, Posey RR, Kyprianou C, O'Sullivan LR, David R, Randle SJ, Polanska UM, Travers J, Urosevic J, Hutchinson JN, Che J, Howley AM, Hasserjian RP, Prantil-Baun R, Ingber DE. Chou DB, et al. Among authors: david r. Nat Commun. 2022 Oct 12;13(1):6021. doi: 10.1038/s41467-022-33672-4. Nat Commun. 2022. PMID: 36224199 Free PMC article.
These data show that hematopoietic cell-intrinsic expression of ABC transporters may be an important factor that determines how some Aurora kinase inhibitors affect the bone marrow....
These data show that hematopoietic cell-intrinsic expression of ABC transporters may be an important factor that determines how some Aurora …
Three dimensional and microphysiological bone marrow models detect in vivo positive compounds.
David R, Gee S, Khan K, Wilson A, Doherty A. David R, et al. Sci Rep. 2021 Nov 9;11(1):21959. doi: 10.1038/s41598-021-01400-5. Sci Rep. 2021. PMID: 34754012 Free PMC article.
Micronucleus (MN) assessment is a valuable tool in safety assessment. However, several compounds are positive in the in vivo bone marrow (BM) MN assay but negative in vitro, reflecting that BM complexity is not recapitulated in vitro. ...
Micronucleus (MN) assessment is a valuable tool in safety assessment. However, several compounds are positive in the in vivo bone …
Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application.
Cairns J, Leonard E, Khan K, Parks C, Maglennon G, Zhang B, Lazic SE, Ewart L, David R. Cairns J, et al. Among authors: david r. Front Pharmacol. 2023 Mar 31;14:1142581. doi: 10.3389/fphar.2023.1142581. eCollection 2023. Front Pharmacol. 2023. PMID: 37063297 Free PMC article.
Methods: As an illustration of how MPS studies can benefit from a systematic evaluation of confounders, we developed an experimental design approach for a bone marrow (BM) MPS and tested it for a specified context of use, the assessment of lineage-specific toxicity. …
Methods: As an illustration of how MPS studies can benefit from a systematic evaluation of confounders, we developed an experimental design …
Increased numbers of bone marrow-derived cells in parathyroid adenoma.
Grabmaier U, Brandl L, Kreiner J, Negele T, Huber BC, Rimmbach C, David R, Brunner S. Grabmaier U, et al. Among authors: david r. Eur J Clin Invest. 2014 Sep;44(9):833-9. doi: 10.1111/eci.12302. Eur J Clin Invest. 2014. PMID: 25047264
BACKGROUND: In primary hyperparathyroidism (PHPT), the increased levels of parathyroid hormone (PTH) result in mobilisation of bone-marrow-derived cells (BMCs) into peripheral blood. However, the fate of these cells is still unknown. ...
BACKGROUND: In primary hyperparathyroidism (PHPT), the increased levels of parathyroid hormone (PTH) result in mobilisation of bone- …
Dose-Independent Therapeutic Benefit of Bone Marrow Stem Cell Transplantation after MI in Mice.
Zarniko N, Skorska A, Steinhoff G, David R, Gaebel R. Zarniko N, et al. Among authors: david r. Biomedicines. 2020 Jun 11;8(6):157. doi: 10.3390/biomedicines8060157. Biomedicines. 2020. PMID: 32545336 Free PMC article.
Several cell populations derived from bone marrow (BM) have been shown to possess cardiac regenerative potential. ...
Several cell populations derived from bone marrow (BM) have been shown to possess cardiac regenerative potential. ...
Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3.
Wolfien M, Klatt D, Salybekov AA, Ii M, Komatsu-Horii M, Gaebel R, Philippou-Massier J, Schrinner E, Akimaru H, Akimaru E, David R, Garbade J, Gummert J, Haverich A, Hennig H, Iwasaki H, Kaminski A, Kawamoto A, Klopsch C, Kowallick JT, Krebs S, Nesteruk J, Reichenspurner H, Ritter C, Stamm C, Tani-Yokoyama A, Blum H, Wolkenhauer O, Schambach A, Asahara T, Steinhoff G. Wolfien M, et al. Among authors: david r. EBioMedicine. 2020 Jul;57:102862. doi: 10.1016/j.ebiom.2020.102862. Epub 2020 Jul 4. EBioMedicine. 2020. PMID: 32629392 Free PMC article. Clinical Trial.
BACKGROUND: Bone marrow stem cell clonal dysfunction by somatic mutation is suspected to affect post-infarction myocardial regeneration after coronary bypass surgery (CABG). ...Preclinical:SH2B3/LNK-silenced hematopoietic stem cell (HSC) clones displayed significant …
BACKGROUND: Bone marrow stem cell clonal dysfunction by somatic mutation is suspected to affect post-infarction myocardial reg …
49 results