Sterol targeting drugs reveal life cycle stage-specific differences in trypanosome lipid rafts.
Sharma AI, Olson CL, Mamede JI, Gazos-Lopes F, Epting CL, Almeida IC, Engman DM.
Sharma AI, et al.
Sci Rep. 2017 Aug 22;7(1):9105. doi: 10.1038/s41598-017-08770-9.
Sci Rep. 2017.
PMID: 28831063
Free PMC article.
T. brucei cycles between its mammalian host (bloodstream cell), in which it scavenges cholesterol, and its tsetse fly host (procyclic cell), in which it both scavenges cholesterol and synthesizes ergosterol. ...
T. brucei cycles between its mammalian host (bloodstream cell), in which it scavenges cholesterol, and its tsetse fly host (procyclic …