APPROACH AND RESULTS: Patients were randomized 1:1:1 to oral seladelpar 5 mg (n=89), 10 mg (n=89), placebo (n=87) daily (with UDCA, as appropriate). Primary end point was a composite biochemical response [alkaline phosphatase (ALP) < 1.67upper limit of normal (ULN), 15%
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daily s. Saldias
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Daisy S. Saldias
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Seladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study.
Hepatology. 2023 Aug 1;78(2):397-415. doi: 10.1097/HEP.0000000000000395. Epub 2023 Apr 6.
Hepatology. 2023.
PMID: 37386786
Free PMC article.
Clinical Trial.
APPROACH AND RESULTS: Patients were randomized 1:1:1 to oral seladelpar 5 mg (n=89), 10 mg (n=89), placebo (n=87) daily (with UDCA, a …
[Validation of a brief screening test to assess functional capacity in Chilean older people].
Herrera P MS, Saldías P, Testa N.
Herrera P MS, et al.
Rev Med Chil. 2014 Sep;142(9):1128-35. doi: 10.4067/S0034-98872014000900006.
Rev Med Chil. 2014.
PMID: 25517052
Free article.
Spanish.
Items with less weight factor and greater gender bias were eliminated, keeping seven questions from the original PFAQ. Reliability was verified using Cronbach alpha's coefficient and from correlations between the new instrument and key variables. ...
Items with less weight factor and greater gender bias were eliminated, keeping seven questions from the original PFAQ. Reliability was verif …
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LANTERN: a randomized study of QVA149 versus salmeterol/fluticasone combination in patients with COPD.
Zhong N, Wang C, Zhou X, Zhang N, Humphries M, Wang L, Thach C, Patalano F, Banerji D; LANTERN Investigators.
Zhong N, et al.
Int J Chron Obstruct Pulmon Dis. 2015 Jun 5;10:1015-26. doi: 10.2147/COPD.S84436. eCollection 2015.
Int J Chron Obstruct Pulmon Dis. 2015.
PMID: 26082625
Free PMC article.
Clinical Trial.
BACKGROUND: The current Global initiative for chronic Obstructive Lung Disease (GOLD) treatment strategy recommends the use of one or more bronchodilators according to the patient's airflow limitation, their history of exacerbations, and symptoms. ...METHODS: In this doubl …
BACKGROUND: The current Global initiative for chronic Obstructive Lung Disease (GOLD) treatment strategy recommends the use of one or more b …
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CT and physiologic determinants of dyspnea and exercise capacity during the six-minute walk test in mild COPD.
Díaz AA, Morales A, Díaz JC, Ramos C, Klaassen J, Saldías F, Aravena C, Díaz R, Lisboa C, Washko GR, Díaz O.
Díaz AA, et al.
Respir Med. 2013 Apr;107(4):570-9. doi: 10.1016/j.rmed.2012.12.011. Epub 2013 Jan 9.
Respir Med. 2013.
PMID: 23313036
Free article.
In regression analysis, dyspnea intensity was best explained by deltaIC and forced expiratory volume in 1 s %predicted. RTMCT-CSA and deltaIC were independent determinants of distance walked. CONCLUSIONS: Among subjects with mild COPD, those with daily-life dyspnea …
In regression analysis, dyspnea intensity was best explained by deltaIC and forced expiratory volume in 1 s %predicted. RTMCT-CSA and …
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