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2009 2
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An experimental model for assessing fibroblast migration in 3-D collagen matrices.
Karamichos D, Lakshman N, Petroll WM. Karamichos D, et al. Cell Motil Cytoskeleton. 2009 Jan;66(1):1-9. doi: 10.1002/cm.20326. Cell Motil Cytoskeleton. 2009. PMID: 19061246 Free PMC article.
The purpose of this study was to develop and test a novel culture model for studying fibroblast migration in 3-D collagen matrices. Human corneal fibroblasts were seeded within dense, randomly oriented compressed collagen matrices. ...Cellular contraction in 10% FBS often …
The purpose of this study was to develop and test a novel culture model for studying fibroblast migration in 3-D collagen matrices. H …
Hypoxia modulates the development of a corneal stromal matrix model.
Lee A, Karamichos D, Onochie OE, Hutcheon AEK, Rich CB, Zieske JD, Trinkaus-Randall V. Lee A, et al. Exp Eye Res. 2018 May;170:127-137. doi: 10.1016/j.exer.2018.02.021. Epub 2018 Feb 27. Exp Eye Res. 2018. PMID: 29496505 Free PMC article.
While many cells respond to a hypoxic state that can occur in a tumor, the cornea is exposed to hypoxia during development prior to eyelid opening and during the diurnal sleep cycle where oxygen levels can drop from 21% to 8%. In this study, we used 2 three-dimensional (3-D …
While many cells respond to a hypoxic state that can occur in a tumor, the cornea is exposed to hypoxia during development prior to eyelid o …
Human corneal fibrosis: an in vitro model.
Karamichos D, Guo XQ, Hutcheon AE, Zieske JD. Karamichos D, et al. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1382-8. doi: 10.1167/iovs.09-3860. Epub 2009 Oct 29. Invest Ophthalmol Vis Sci. 2010. PMID: 19875671 Free PMC article.
TGF-beta1 is known to stimulate overproduction and deposition of ECM components. Previously, an in vitro three-dimensional (3-D) model of a corneal stroma was developed by using primary human corneal fibroblasts (HCFs) stimulated with stable vitamin C (VitC). ...The author …
TGF-beta1 is known to stimulate overproduction and deposition of ECM components. Previously, an in vitro three-dimensional (3-D) mode …
Prospective Observational Study Evaluating Systemic Hormones and Corneal Crosslinking Effects in Keratoconus.
Van L, Bennett S, Nicholas SE, Hjortdal J, McKay TB, Karamichos D. Van L, et al. Ophthalmol Sci. 2023 Jul 11;4(2):100364. doi: 10.1016/j.xops.2023.100364. eCollection 2024 Mar-Apr. Ophthalmol Sci. 2023. PMID: 37868794 Free PMC article.
RESULTS: Corneal collagen crosslinking was associated with a 2% reduction in K(max) values in the CXL eye, post-CXL, from baseline (median, 56.8 diopters [D]; 95% confidence interval [CI], 50.4-60.3) to the second visit (55.7 D; 95% CI, 50.4-58.8; P < 0.001). ...
RESULTS: Corneal collagen crosslinking was associated with a 2% reduction in K(max) values in the CXL eye, post-CXL, from baseline (median, …
Human in vitro Model Reveals the Effects of Collagen Cross-linking on Keratoconus Pathogenesis.
Sharif R, Hjortdal J, Sejersen H, Frank G, Karamichos D. Sharif R, et al. Sci Rep. 2017 Oct 2;7(1):12517. doi: 10.1038/s41598-017-12598-8. Sci Rep. 2017. PMID: 28970517 Free PMC article.
In order to evaluate the effect of CXL on human corneal stromal cells in vitro, we developed a 3-D in vitro CXL model, using primary Human corneal fibroblasts (HCFs) from healthy patients and Human Keratoconus fibroblasts (HKCs) from KC patients. ...Furthermore, a signific …
In order to evaluate the effect of CXL on human corneal stromal cells in vitro, we developed a 3-D in vitro CXL model, using primary …
Complete metabolome and lipidome analysis reveals novel biomarkers in the human diabetic corneal stroma.
Priyadarsini S, McKay TB, Sarker-Nag A, Allegood J, Chalfant C, Ma JX, Karamichos D. Priyadarsini S, et al. Exp Eye Res. 2016 Dec;153:90-100. doi: 10.1016/j.exer.2016.10.010. Epub 2016 Oct 11. Exp Eye Res. 2016. PMID: 27742548 Free PMC article.
We also found significant upregulation of novel biomarkers aminoadipic acid, D,L-pipecolic acid, and dihydroorotate. Our study links aberrant tryptophan metabolism to end-stage pathologies associated with diabetes indicating the potential of the Kynurenine pathway as a the …
We also found significant upregulation of novel biomarkers aminoadipic acid, D,L-pipecolic acid, and dihydroorotate. Our study links …
12 results