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Short-Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart.
Carley AN, Maurya SK, Fasano M, Wang Y, Selzman CH, Drakos SG, Lewandowski ED. Carley AN, et al. Circulation. 2021 May 4;143(18):1797-1808. doi: 10.1161/CIRCULATIONAHA.120.052671. Epub 2021 Feb 19. Circulation. 2021. PMID: 33601938 Free PMC article.
Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
WHO Solidarity Trial Consortium; Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, Abdool Karim Q, Alejandria MM, Hernández García C, Kieny MP, Malekzadeh R, Murthy S, Reddy KS, Roses Periago M, Abi Hanna P, Ader F, Al-Bader AM, Alhasawi A, Allum E, Alotaibi A, Alvarez-Moreno CA, Appadoo S, Asiri A, Aukrust P, Barratt-Due A, Bellani S, Branca M, Cappel-Porter HBC, Cerrato N, Chow TS, Como N, Eustace J, García PJ, Godbole S, Gotuzzo E, Griskevicius L, Hamra R, Hassan M, Hassany M, Hutton D, Irmansyah I, Jancoriene L, Kirwan J, Kumar S, Lennon P, Lopardo G, Lydon P, Magrini N, Maguire T, Manevska S, Manuel O, McGinty S, Medina MT, Mesa Rubio ML, Miranda-Montoya MC, Nel J, Nunes EP, Perola M, Portolés A, Rasmin MR, Raza A, Rees H, Reges PPS, Rogers CA, Salami K, Salvadori MI, Sinani N, Sterne JAC, Stevanovikj M, Tacconelli E, Tikkinen KAO, Trelle S, Zaid H, Røttingen JA, Swaminathan S. WHO Solidarity Trial Consortium, et al. N Engl J Med. 2021 Feb 11;384(6):497-511. doi: 10.1056/NEJMoa2023184. Epub 2020 Dec 2. N Engl J Med. 2021. PMID: 33264556 Free PMC article. Clinical Trial.
Sarcolipin protein interaction with sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) is distinct from phospholamban protein, and only sarcolipin can promote uncoupling of the SERCA pump.
Sahoo SK, Shaikh SA, Sopariwala DH, Bal NC, Periasamy M. Sahoo SK, et al. J Biol Chem. 2013 Mar 8;288(10):6881-9. doi: 10.1074/jbc.M112.436915. Epub 2013 Jan 22. J Biol Chem. 2013. PMID: 23341466 Free PMC article.
Recent data suggest that SLN could play a role in muscle thermogenesis by promoting uncoupling of the SERCA pump (Lee, A.G. (2002) Curr. Opin. Struct. Biol. 12, 547-554 and Bal, N. C., Maurya, S. K., Sopariwala, D. H., Sahoo, S. K., Gupta, S. C., Shaik …
Recent data suggest that SLN could play a role in muscle thermogenesis by promoting uncoupling of the SERCA pump (Lee, A.G. (2002) Curr. Opi …
Targeting Artemisinin-Resistant Malaria by Repurposing the Anti-Hepatitis C Virus Drug Alisporivir.
Chaurasiya A, Kumari G, Garg S, Shoaib R, Anam Z, Joshi N, Kumari J, Singhal J, Singh N, Kaushik S, Kahlon AK, Dubey N, Maurya MK, Srivastava P, Marothia M, Joshi P, Gupta K, Saini S, Das G, Bhattacharjee S, Singh S, Ranganathan A. Chaurasiya A, et al. Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0039222. doi: 10.1128/aac.00392-22. Epub 2022 Nov 14. Antimicrob Agents Chemother. 2022. PMID: 36374050 Free PMC article.
In silico docking studies and molecular dynamic simulation predicted strong interaction of alisporivir with PfCyclophilin 19B, confirmed through biophysical assays with a K(d) value of 354.3 nM. Alisporivir showed potent antimalarial activity against chloroquine-res …
In silico docking studies and molecular dynamic simulation predicted strong interaction of alisporivir with PfCyclophilin 19B, confirmed thr …
The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India.
Zhang Y, Vaidya N, Iyengar U, Sharma E, Holla B, Ahuja CK, Barker GJ, Basu D, Bharath RD, Chakrabarti A, Desrivieres S, Elliott P, Fernandes G, Gourisankar A, Heron J, Hickman M, Jacob P, Jain S, Jayarajan D, Kalyanram K, Kartik K, Krishna M, Krishnaveni G, Kumar K, Kumaran K, Kuriyan R, Murthy P, Orfanos DP, Purushottam M, Rangaswamy M, Kupard SS, Singh L, Singh R, Subodh BN, Thennarasu K, Toledano M, Varghese M, Benegal V, Schumann G; c-VEDA consortium. Zhang Y, et al. Mol Psychiatry. 2020 Aug;25(8):1618-1630. doi: 10.1038/s41380-020-0656-1. Epub 2020 Mar 12. Mol Psychiatry. 2020. PMID: 32203154 Review.
Anti-ulcer constituents of Annona squamosa twigs.
Yadav DK, Singh N, Dev K, Sharma R, Sahai M, Palit G, Maurya R. Yadav DK, et al. Fitoterapia. 2011 Jun;82(4):666-75. doi: 10.1016/j.fitote.2011.02.005. Epub 2011 Feb 20. Fitoterapia. 2011. PMID: 21342663
Phytochemical investigation of Annona squamosa twigs, resulted in isolation and identification of twelve known (1-12) compounds among them one 1-(4-beta-D-glucopyranosyloxyphenyl)-2-(beta-D-glucopyranosyloxy)-ethane (11) is synthetically known but first time isolate …
Phytochemical investigation of Annona squamosa twigs, resulted in isolation and identification of twelve known (1-12) compounds among them o …
DrRecQ regulates guanine quadruplex DNA structure dynamics and its impact on radioresistance in Deinococcus radiodurans.
Khairnar NP, Maurya GK, Pandey N, Das A, Misra HS. Khairnar NP, et al. Mol Microbiol. 2019 Sep;112(3):854-865. doi: 10.1111/mmi.14321. Epub 2019 Jun 19. Mol Microbiol. 2019. PMID: 31162841 Free article.
The recombinant drRecQ showed ~400 times higher affinity to G4 DNA (K(d) = 11.74 1.77 nM) as compared to dsDNA (K(d) = 4.88 1.30 M). drRecQ showed ATP independent helicase function on G4 DNA, which was higher than ATP-dependent helicase activity on dsD …
The recombinant drRecQ showed ~400 times higher affinity to G4 DNA (K(d) = 11.74 1.77 nM) as compared to dsDNA (K(d …
beta-Sitosterol-D-Glucopyranoside Mimics Estrogenic Properties and Stimulates Glucose Utilization in Skeletal Muscle Cells.
Pandey J, Dev K, Chattopadhyay S, Kadan S, Sharma T, Maurya R, Sanyal S, Siddiqi MI, Zaid H, Tamrakar AK. Pandey J, et al. Molecules. 2021 May 24;26(11):3129. doi: 10.3390/molecules26113129. Molecules. 2021. PMID: 34073781 Free PMC article.
Here, we investigated the estrogenic effect of beta-sitosterol-3-O-D-glucopyranoside (BSD), isolated from the fruits of Cupressus sempervirens and monitored its ability to regulate glucose utilization in skeletal muscle cells. ...The BSD-mediated biological response to inc …
Here, we investigated the estrogenic effect of beta-sitosterol-3-O-D-glucopyranoside (BSD), isolated from the fruits of Cupressus sem …
21 results