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Showing results for damage araya
Your search for Dámare Araya retrieved no results
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Wakui H, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. Araya J, et al. Autophagy. 2019 Mar;15(3):510-526. doi: 10.1080/15548627.2018.1532259. Epub 2018 Oct 13. Autophagy. 2019. PMID: 30290714 Free PMC article.
Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays a crucial role in eliminating damaged mitochondria, and is governed by the PINK1 (PTEN induced …
Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely implicated in chronic obstructive pulmonary disease …
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens.
Morgens DW, Wainberg M, Boyle EA, Ursu O, Araya CL, Tsui CK, Haney MS, Hess GT, Han K, Jeng EE, Li A, Snyder MP, Greenleaf WJ, Kundaje A, Bassik MC. Morgens DW, et al. Nat Commun. 2017 May 5;8:15178. doi: 10.1038/ncomms15178. Nat Commun. 2017. PMID: 28474669 Free PMC article.
CRISPR-Cas9 screens are powerful tools for high-throughput interrogation of genome function, but can be confounded by nuclease-induced toxicity at both on- and off-target sites, likely due to DNA damage. Here, to test potential solutions to this issue, we design and analys …
CRISPR-Cas9 screens are powerful tools for high-throughput interrogation of genome function, but can be confounded by nuclease-induced toxic …
Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia.
Ito A, Hashimoto M, Tanihata J, Matsubayashi S, Sasaki R, Fujimoto S, Kawamoto H, Hosaka Y, Ichikawa A, Kadota T, Fujita Y, Takekoshi D, Ito S, Minagawa S, Numata T, Hara H, Matsuoka T, Udaka J, Araya J, Saito M, Kuwano K. Ito A, et al. J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1864-1882. doi: 10.1002/jcsm.12988. Epub 2022 Apr 3. J Cachexia Sarcopenia Muscle. 2022. PMID: 35373498 Free PMC article.
Parkin-mediated mitophagy regulated myotube atrophy by modulating mitochondrial damage and mitochondrial ROS production. Increased mitochondrial ROS was responsible for myotube atrophy by activating Muscle Ring Finger 1 (MuRF-1)-mediated myosin heavy chain (MHC) degradatio …
Parkin-mediated mitophagy regulated myotube atrophy by modulating mitochondrial damage and mitochondrial ROS production. Increased mi …
Mitochondrial dysfunction in neurodegenerative disorders: Potential therapeutic application of mitochondrial transfer to central nervous system-residing cells.
Bustamante-Barrientos FA, Luque-Campos N, Araya MJ, Lara-Barba E, de Solminihac J, Pradenas C, Molina L, Herrera-Luna Y, Utreras-Mendoza Y, Elizondo-Vega R, Vega-Letter AM, Luz-Crawford P. Bustamante-Barrientos FA, et al. J Transl Med. 2023 Sep 9;21(1):613. doi: 10.1186/s12967-023-04493-w. J Transl Med. 2023. PMID: 37689642 Free PMC article. Review.
Mitochondrial transfer offers an overall solution since it contains the replacement of damage mitochondria by healthy units. Therefore, this review provides an introducing view on the structure and energy-related functions of mitochondria as well as their dynamics. ...
Mitochondrial transfer offers an overall solution since it contains the replacement of damage mitochondria by healthy units. Therefor …
Mitochondrial Quality Control in COPD and IPF.
Hara H, Kuwano K, Araya J. Hara H, et al. Cells. 2018 Jul 24;7(8):86. doi: 10.3390/cells7080086. Cells. 2018. PMID: 30042371 Free PMC article. Review.
Mitochondria fuse to increase energy production in response to stress, and damaged mitochondria are segregated by fission and degraded by mitophagy. ...
Mitochondria fuse to increase energy production in response to stress, and damaged mitochondria are segregated by fission and degrade …
PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses.
Tsubouchi K, Araya J, Kuwano K. Tsubouchi K, et al. Inflamm Regen. 2018 Oct 24;38:18. doi: 10.1186/s41232-018-0077-6. eCollection 2018. Inflamm Regen. 2018. PMID: 30386443 Free PMC article. Review.
Dysregulation of mechanisms for mitochondrial integrity, including mitophagy, induces accumulation of mitochondrial damage. Mitophagy is a highly conserved mechanism of selectively delivering damaged mitochondria for lysosomal degradation and is mainly governed by p …
Dysregulation of mechanisms for mitochondrial integrity, including mitophagy, induces accumulation of mitochondrial damage. Mitophagy …
Divergent roles of the Hippo pathway in the pathogenesis of idiopathic pulmonary fibrosis: tissue homeostasis and fibrosis.
Kizawa R, Araya J, Fujita Y. Kizawa R, et al. Inflamm Regen. 2023 Sep 21;43(1):45. doi: 10.1186/s41232-023-00295-1. Inflamm Regen. 2023. PMID: 37735707 Free PMC article. Review.
Epithelial cells normally maintain homeostasis of the lung tissue through regulated proliferation, differentiation, cell death, and cellular senescence. However, various stresses can cause repetitive damage to lung epithelial cells, leading to dysfunctional regeneration an …
Epithelial cells normally maintain homeostasis of the lung tissue through regulated proliferation, differentiation, cell death, and cellular …
Specialized interferon action in COVID-19.
Galbraith MD, Kinning KT, Sullivan KD, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Guo K, Wilson CC, Santiago ML, Monte AA, Bennett TD, Hansen KC, Hsieh EWY, D'Alessandro A, Espinosa JM. Galbraith MD, et al. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2116730119. doi: 10.1073/pnas.2116730119. Proc Natl Acad Sci U S A. 2022. PMID: 35217532 Free PMC article.
In contrast, proteomics signatures indicative of endothelial damage and platelet activation associate with high levels of IFNB1 and IFNA6. ...
In contrast, proteomics signatures indicative of endothelial damage and platelet activation associate with high levels of IFNB1 and I …
Extracellular vesicle-mediated cellular crosstalk in lung repair, remodelling and regeneration.
Kadota T, Fujita Y, Araya J, Ochiya T, Kuwano K. Kadota T, et al. Eur Respir Rev. 2022 Jan 25;31(163):210106. doi: 10.1183/16000617.0106-2021. Print 2022 Mar 31. Eur Respir Rev. 2022. PMID: 35082125 Free PMC article. Review.
The unperturbed lung is highly quiescent, with a remarkably low level of cell turnover. However, once damaged, the lung shows an extensive regenerative capacity, with resident progenitor cell populations re-entering the cell cycle and differentiating to promote repair. ...
The unperturbed lung is highly quiescent, with a remarkably low level of cell turnover. However, once damaged, the lung shows an exte …
The COVIDome Explorer Researcher Portal.
Sullivan KD, Galbraith MD, Kinning KT, Bartsch K, Levinsky N, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Monte AA, Bennett TD, Miller MG, Hsieh EWY, D'Alessandro A, Hansen KC, Espinosa JM. Sullivan KD, et al. medRxiv [Preprint]. 2021 Mar 8:2021.03.04.21252945. doi: 10.1101/2021.03.04.21252945. medRxiv. 2021. PMID: 33758879 Free PMC article. Updated. Preprint.
We illustrate here the use of the COVIDome dataset through a multi-omics analysis of biosignatures associated with C-reactive protein (CRP), an established marker of poor prognosis in COVID-19, revealing associations between CRP levels and damage-associated molecular patte …
We illustrate here the use of the COVIDome dataset through a multi-omics analysis of biosignatures associated with C-reactive protein (CRP), …
91 results