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Year Number of Results
2013 3
2014 3
2015 1
2016 4
2017 1
2024 0

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Page 1
Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities.
Gupton JT, Yeudall S, Telang N, Hoerrner M, Huff E, Crawford E, Lounsbury K, Kimmel M, Curry W, Harrison A, Juekun W, Shimozono A, Ortolani J, Lescalleet K, Patteson J, Moore-Stoll V, Rohena CC, Mooberry SL, Obaidullah AJ, Kellogg GE, Sikorski JA. Gupton JT, et al. Among authors: rohena cc. Bioorg Med Chem. 2017 Jun 15;25(12):3206-3214. doi: 10.1016/j.bmc.2017.04.012. Epub 2017 Apr 11. Bioorg Med Chem. 2017. PMID: 28433513 Free PMC article.
Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.
Devambatla RK, Namjoshi OA, Choudhary S, Hamel E, Shaffer CV, Rohena CC, Mooberry SL, Gangjee A. Devambatla RK, et al. Among authors: rohena cc. J Med Chem. 2016 Jun 23;59(12):5752-65. doi: 10.1021/acs.jmedchem.6b00237. Epub 2016 Jun 7. J Med Chem. 2016. PMID: 27213719 Free PMC article.
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. Zhang X, et al. Among authors: rohena cc. Bioorg Med Chem. 2014 Jul 15;22(14):3753-72. doi: 10.1016/j.bmc.2014.04.049. Epub 2014 May 14. Bioorg Med Chem. 2014. PMID: 24890652 Free PMC article.
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.
Gangjee A, Zhao Y, Raghavan S, Rohena CC, Mooberry SL, Hamel E. Gangjee A, et al. Among authors: rohena cc. J Med Chem. 2013 Sep 12;56(17):6829-44. doi: 10.1021/jm400639z. Epub 2013 Aug 29. J Med Chem. 2013. PMID: 23895532 Free PMC article.
11 results