Reciprocal homeostatic responses to excitatory synaptic receptor inactivation in developing organotypic cortical networks in vitro

Michael Alan Corner

doi:10.1016/j.neulet.2008.04.062

Reciprocal homeostatic responses to excitatory synaptic receptor inactivation in developing organotypic cortical networks in vitro

Neurosci Lett. 2008 Jun 27;438(3):300-2. doi: 10.1016/j.neulet.2008.04.062. Epub 2008 Apr 23.

Author

Michael Alan Corner¹

Affiliation

¹ Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands. m.corner@hccnet.nl

PMID: 18485594
DOI: 10.1016/j.neulet.2008.04.062

Abstract

Chronic blockade of actively excitatory glutamatergic synaptic receptors in co-cultured organotypic rodent neocortex explants rapidly leads to a compensatory sensitization of otherwise inactive input channels so as to maintain ongoing action potential bursts. We report here that the homeostatic return of spontaneous, kainate receptor driven, spike discharges is followed by a reciprocal desensitization of blocked AMPA and NMDA receptors, such that the developing network is protected against becoming hyperactive once full synaptic drive is restored.

MeSH terms

Action Potentials / drug effects
Action Potentials / physiology
Animals
Animals, Newborn
Drug Interactions
Excitatory Amino Acid Antagonists / pharmacology
Homeostasis / drug effects
Homeostasis / physiology*
Nerve Net / drug effects
Nerve Net / physiology*
Organ Culture Techniques
Periodicity
Rats
Receptors, Glutamate / classification
Receptors, Glutamate / physiology*
Statistics, Nonparametric
Time Factors
Visual Cortex / drug effects
Visual Cortex / physiology*

Substances

Excitatory Amino Acid Antagonists
Receptors, Glutamate