Abstract
Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / metabolism*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Benzodioxoles / chemistry
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Benzodioxoles / metabolism*
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Benzodioxoles / pharmacology*
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Cell Line, Tumor
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Fatty Acids, Unsaturated / chemistry
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Fatty Acids, Unsaturated / isolation & purification
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Fatty Acids, Unsaturated / pharmacology*
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Humans
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Piper nigrum / chemistry*
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Piperidines / chemistry
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Piperidines / metabolism*
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Piperidines / pharmacology*
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Polyunsaturated Alkamides / chemistry
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Polyunsaturated Alkamides / isolation & purification
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Polyunsaturated Alkamides / metabolism*
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Polyunsaturated Alkamides / pharmacology*
Substances
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5-(3,4-(methylenedioxy)phenyl)-pent-2-ene piperidine
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Alkaloids
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Antineoplastic Agents
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Benzodioxoles
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Fatty Acids, Unsaturated
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Piperidines
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Polyunsaturated Alkamides
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pellitorine
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piperine