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Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators.
Peltner LK, Gluthmann L, Börner F, Pace S, Hoffstetter RK, Kretzer C, Bilancia R, Pollastro F, Koeberle A, Appendino G, Rossi A, Newcomer ME, Gilbert NC, Werz O, Jordan PM. Peltner LK, et al. Among authors: kretzer c. Cell Chem Biol. 2023 Dec 21;30(12):1508-1524.e7. doi: 10.1016/j.chembiol.2023.08.001. Epub 2023 Aug 29. Cell Chem Biol. 2023. PMID: 37647900
Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors.
Potenza M, Giordano A, Chini MG, Saviano A, Kretzer C, Raucci F, Russo M, Lauro G, Terracciano S, Bruno I, Iorizzi M, Hofstetter RK, Pace S, Maione F, Werz O, Bifulco G. Potenza M, et al. Among authors: kretzer c. ACS Med Chem Lett. 2022 Dec 9;14(1):26-34. doi: 10.1021/acsmedchemlett.2c00343. eCollection 2023 Jan 12. ACS Med Chem Lett. 2022. PMID: 36655121 Free PMC article.
Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages.
Kretzer C, Jordan PM, Meyer KPL, Hoff D, Werner M, Hofstetter RK, Koeberle A, Cala Peralta A, Viault G, Seraphin D, Richomme P, Helesbeux JJ, Stuppner H, Temml V, Schuster D, Werz O. Kretzer C, et al. Biochem Pharmacol. 2022 Jan;195:114825. doi: 10.1016/j.bcp.2021.114825. Epub 2021 Nov 8. Biochem Pharmacol. 2022. PMID: 34762841
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators.
Pace S, Zhang K, Jordan PM, Bilancia R, Wang W, Börner F, Hofstetter RK, Potenza M, Kretzer C, Gerstmeier J, Fischer D, Lorkowski S, Gilbert NC, Newcomer ME, Rossi A, Chen X, Werz O. Pace S, et al. Among authors: kretzer c. Pharmacol Res. 2021 May;167:105556. doi: 10.1016/j.phrs.2021.105556. Epub 2021 Mar 31. Pharmacol Res. 2021. PMID: 33812006
22 results