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Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit.
Cancer Gene Ther. 2022 Jul;29(7):1021-1032. doi: 10.1038/s41417-021-00409-2. Epub 2021 Nov 26.
Cancer Gene Ther. 2022.
PMID: 34837065
Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents.
Omran Z, Guise CP, Chen L, Rauch C, Abdalla AN, Abdullah O, Sindi IA, Fischer PM, Smaill JB, Patterson AV, Liu Y, Wang Q.
Omran Z, et al. Among authors: guise cp.
Molecules. 2021 Jun 1;26(11):3327. doi: 10.3390/molecules26113327.
Molecules. 2021.
PMID: 34206005
Free PMC article.
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Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity.
Guise CP, Abbattista MR, Anderson RF, Li D, Taghipouran R, Tsai A, Lee SJ, Smaill JB, Denny WA, Hay MP, Wilson WR, Hicks KO, Patterson AV.
Guise CP, et al.
Molecules. 2020 Oct 22;25(21):4888. doi: 10.3390/molecules25214888.
Molecules. 2020.
PMID: 33105798
Free PMC article.
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The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104.
Foehrenbacher A, Patel K, Abbattista MR, Guise CP, Secomb TW, Wilson WR, Hicks KO.
Foehrenbacher A, et al. Among authors: guise cp.
Front Oncol. 2013 Oct 7;3:263. doi: 10.3389/fonc.2013.00263. eCollection 2013.
Front Oncol. 2013.
PMID: 24109591
Free PMC article.
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Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5.
Wang J, Guise CP, Dachs GU, Phung Y, Hsu AH, Lambie NK, Patterson AV, Wilson WR.
Wang J, et al. Among authors: guise cp.
Biochem Pharmacol. 2014 Oct 15;91(4):436-46. doi: 10.1016/j.bcp.2014.08.003. Epub 2014 Aug 15.
Biochem Pharmacol. 2014.
PMID: 25130546
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Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: a role for NADPH:cytochrome P450 oxidoreductase under hypoxia.
Guise CP, Wang AT, Theil A, Bridewell DJ, Wilson WR, Patterson AV.
Guise CP, et al.
Biochem Pharmacol. 2007 Sep 15;74(6):810-20. doi: 10.1016/j.bcp.2007.06.014. Epub 2007 Jun 17.
Biochem Pharmacol. 2007.
PMID: 17645874
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