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A siRNA targets and inhibits a broad range of SARS-CoV-2 infections including Delta variant.
Chang YC, Yang CF, Chen YF, Yang CC, Chou YL, Chou HW, Chang TY, Chao TL, Hsu SC, Ieong SM, Tsai YM, Liu PC, Chin YF, Fang JT, Kao HC, Lu HY, Chang JY, Weng RS, Tu QW, Chang FY, Huang KY, Lee TY, Chang SY, Yang PC. Chang YC, et al. Among authors: chin yf. EMBO Mol Med. 2022 Apr 7;14(4):e15298. doi: 10.15252/emmm.202115298. Epub 2022 Feb 21. EMBO Mol Med. 2022. PMID: 35138028 Free PMC article.
Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model.
Chen YT, Chang YH, Pathak N, Tzou SC, Luo YC, Hsu YC, Li TN, Lee JY, Chen YC, Huang YW, Yang HJ, Hsu NY, Tsai HP, Chang TY, Hsu SC, Liu PC, Chin YF, Lin WC, Yang CM, Wu HL, Lee CY, Hsu HL, Liu YC, Chu JW, Wang LH, Wang JY, Huang CH, Lin CH, Hsieh PS, Wu Lee YH, Hung YJ, Yang JM. Chen YT, et al. Among authors: chin yf. Front Immunol. 2022 Dec 21;13:1080897. doi: 10.3389/fimmu.2022.1080897. eCollection 2022. Front Immunol. 2022. PMID: 36618412 Free PMC article.
BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir.
Tang W-F, Chang Y-H, Lin C-C, Jheng J-R, Hsieh C-F, Chin Y-F, Chang T-Y, Lee J-C, Liang P-H, Lin C-Y, Lin G-H, Cai J-Y, Chen Y-L, Chen Y-S, Tsai S-K, Liu P-C, Yang C-M, Shadbahr T, Tang J, Hsu Y-L, Huang C-H, Wang L-Y, Chen CC, Kau J-H, Hung Y-J, Lee H-Y, Wang W-C, Tsai H-P, Horng J-T. Tang W-F, et al. Among authors: chin y f. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0095623. doi: 10.1128/aac.00956-23. Epub 2024 Mar 6. Antimicrob Agents Chemother. 2024. PMID: 38446062 Free PMC article.