Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)

Biomarkers. 2013 Feb;18(1):63-72. doi: 10.3109/1354750X.2012.737025. Epub 2012 Nov 2.

Abstract

Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated.

Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues.

Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively.

Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers, Tumor / metabolism*
  • Carcinoma, Squamous Cell / metabolism*
  • Case-Control Studies
  • Female
  • Fibronectins / metabolism*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Hyaluronan Receptors / metabolism*
  • Integrin alpha4beta1 / metabolism*
  • Male
  • Middle Aged
  • Mouth / metabolism
  • Mouth Neoplasms / metabolism*
  • Sensitivity and Specificity
  • Syndecan-2 / metabolism*

Substances

  • Biomarkers, Tumor
  • CD44 protein, human
  • FN1 protein, human
  • Fibronectins
  • Hyaluronan Receptors
  • Integrin alpha4beta1
  • Syndecan-2