Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7.
Zhang Z, Fan Y, Xie F, Zhou H, Jin K, Shao L, Shi W, Fang P, Yang B, van Dam H, Ten Dijke P, Zheng X, Yan X, Jia J, Zheng M, Jin J, Ding C, Ye S, Zhou F, Zhang L.
Zhang Z, et al. Among authors: yang b.
Nat Commun. 2017 Dec 13;8(1):2116. doi: 10.1038/s41467-017-02029-7.
Nat Commun. 2017.
PMID: 29235476
Free PMC article.
Further investigation reveals that OTUD1 directly deubiquitinates the TGF-beta pathway inhibitor SMAD7 and prevents its degradation. Moreover, OTUD1 cleaves Lysine 33-linked poly-ubiquitin chains of SMAD7 Lysine 220, which exposes the SMAD7 PY motif, enabling SMURF2 bindin …
Further investigation reveals that OTUD1 directly deubiquitinates the TGF-beta pathway inhibitor SMAD7 and prevents its degradation. Moreove …