New sterols from the South China Sea sponges Halichondria sp

Bao Chen; Wang-Sheng Li; Yu-Cheng Gu; Hai-Yan Zhang; Hui Luo; Chang-Yun Wang; Yue-Wei Guo

doi:10.1016/j.fitote.2021.104918

New sterols from the South China Sea sponges Halichondria sp

Fitoterapia. 2021 Jul:152:104918. doi: 10.1016/j.fitote.2021.104918. Epub 2021 May 11.

Authors

Bao Chen¹, Wang-Sheng Li², Yu-Cheng Gu³, Hai-Yan Zhang⁴, Hui Luo⁵, Chang-Yun Wang⁶, Yue-Wei Guo⁷

Affiliations

¹ Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu GulfRim, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.
³ Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom.
⁴ CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
⁵ The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu GulfRim, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.
⁶ Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China. Electronic address: changyun@ouc.edu.cn.
⁷ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China. Electronic address: ywguo@simm.ac.cn.

PMID: 33984436
DOI: 10.1016/j.fitote.2021.104918

Abstract

A detailed chemical investigation of two specimen of South China Sea sponges Halichondria sp. (No. 19-XD-47 and No. 17-XD-87) have resulted in the isolation of three new sterols, namely, halichsterols A (1), B (2) and C (3), together with seven related known ones (4-10). Their structures were determined by extensive spectroscopic analysis and by comparison with the spectral data reported in the literature. In bioassay, compound 2 displayed significantly anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.

Keywords: Anti-inflammatory activity; Halichondria sp.; Sponge; Sterols.

MeSH terms

Animals
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Cell Line
China
Mice
Microglia / drug effects*
Molecular Structure
Pacific Ocean
Porifera / chemistry*
Sterols / isolation & purification
Sterols / pharmacology*

Substances

Anti-Inflammatory Agents
Sterols