Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix

Harry J Gould 3rd; Paige R Miller; Samantha Edenfield; Kelly Jean Sherman; Chad K Brady; Dennis Paul

doi:10.3390/curroncol28030196

Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix

Curr Oncol. 2021 Jun 8;28(3):2115-2122. doi: 10.3390/curroncol28030196.

Authors

Harry J Gould 3rd^{1

2}, Paige R Miller², Samantha Edenfield³, Kelly Jean Sherman³, Chad K Brady⁴, Dennis Paul^{2

3}

Affiliations

¹ Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
² Oleander Medical Technologies, Baton Rouge, LA 70803, USA.
³ Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
⁴ Department of Radiology, West Virginia University Medical School, Morgantown, WV 26506, USA.

Abstract

Upregulation of voltage-gated sodium channels (VGSCs) and Na⁺/K⁺-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas.

Trial registration: ClinicalTrials.gov NCT01414608.

Keywords: advanced-stage cervical cancer; sodium channels; sodium pumps; targeted osmotic lysis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Squamous Cell*
Female
Humans
Sodium / metabolism
Uterine Cervical Neoplasms* / drug therapy
Voltage-Gated Sodium Channels*

Substances

Voltage-Gated Sodium Channels
Sodium

Associated data

ClinicalTrials.gov/NCT01414608