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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 2
1953 1
1954 1
1956 1
1958 2
1959 1
1962 2
1964 1
1968 1
1970 1
1972 1
1974 5
1975 2
1976 4
1977 1
1978 6
1979 2
1980 4
1981 8
1982 8
1983 6
1984 5
1985 5
1986 4
1987 8
1988 6
1989 4
1990 10
1991 7
1992 8
1993 7
1994 12
1995 17
1996 19
1997 18
1998 15
1999 22
2000 25
2001 36
2002 34
2003 30
2004 36
2005 26
2006 49
2007 58
2008 40
2009 65
2010 56
2011 72
2012 82
2013 99
2014 104
2015 94
2016 114
2017 118
2018 98
2019 96
2020 123
2021 104
2022 56
2023 51
2024 14

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1,697 results

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Page 1
The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond.
Löscher W, Klein P. Löscher W, et al. CNS Drugs. 2021 Sep;35(9):935-963. doi: 10.1007/s40263-021-00827-8. Epub 2021 Jun 18. CNS Drugs. 2021. PMID: 34145528 Free PMC article. Review.
Because of differences in their mechanisms of action, most ASMs do not suppress all types of seizures, so appropriate treatment choices are important. The goal of epilepsy therapy is the complete elimination of seizures; however, this is not achievable in about one-third o …
Because of differences in their mechanisms of action, most ASMs do not suppress all types of seizures, so appropriate treatment choices are …
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA. Vassilev LT, et al. Science. 2004 Feb 6;303(5659):844-8. doi: 10.1126/science.1092472. Epub 2004 Jan 2. Science. 2004. PMID: 14704432
Inhibition of MDM2-p53 interaction can stabilize p53 and may offer a novel strategy for cancer therapy. Here, we identify potent and selective small-molecule antagonists of MDM2 and confirm their mode of action through the crystal structures of complexes. ...
Inhibition of MDM2-p53 interaction can stabilize p53 and may offer a novel strategy for cancer therapy. Here, we identify potent and …
Phenserine.
Klein J. Klein J. Expert Opin Investig Drugs. 2007 Jul;16(7):1087-97. doi: 10.1517/13543784.16.7.1087. Expert Opin Investig Drugs. 2007. PMID: 17594192 Review.
Echinacea reduces antibiotic usage in children through respiratory tract infection prevention: a randomized, blinded, controlled clinical trial.
Ogal M, Johnston SL, Klein P, Schoop R. Ogal M, et al. Eur J Med Res. 2021 Apr 8;26(1):33. doi: 10.1186/s40001-021-00499-6. Eur J Med Res. 2021. PMID: 33832544 Free PMC article. Clinical Trial.

Six children (5.8%) with Echinacea and 15 children (15.3%) with vitamin C required 6 and 24 courses of antibiotic treatment, respectively (reduction of 76.3%, p < 0.001). A total of 45 and 216 days of antibiotic therapy were reported in the two groups, respectively (red

…
Six children (5.8%) with Echinacea and 15 children (15.3%) with vitamin C required 6 and 24 courses of antibiotic treatment, respectively (r …
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia.
Kelly MJ, Pietranico-Cole S, Larigan JD, Haynes NE, Reynolds CH, Scott N, Vermeulen J, Dvorozniak M, Conde-Knape K, Huang KS, So SS, Thakkar K, Qian Y, Banner B, Mennona F, Danzi S, Klein I, Taub R, Tilley J. Kelly MJ, et al. J Med Chem. 2014 May 22;57(10):3912-23. doi: 10.1021/jm4019299. Epub 2014 Apr 8. J Med Chem. 2014. PMID: 24712661
The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor beta (THR-beta) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor alpha (THR-alpha). ...
The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor beta ( …
Marijuana and the Pediatric Population.
Dharmapuri S, Miller K, Klein JD. Dharmapuri S, et al. Pediatrics. 2020 Aug;146(2):e20192629. doi: 10.1542/peds.2019-2629. Epub 2020 Jul 13. Pediatrics. 2020. PMID: 32661188 Review.
[Insulin therapy-new insulin analogues].
Ehren M, Klein HH. Ehren M, et al. Internist (Berl). 2019 Sep;60(9):887-894. doi: 10.1007/s00108-019-0652-1. Internist (Berl). 2019. PMID: 31396651 Review. German.
1,697 results