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Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome.
Pharmaceuticals (Basel). 2010 Jun 4;3(6):1842-1872. doi: 10.3390/ph3061842.
Pharmaceuticals (Basel). 2010.
PMID: 27713332
Free PMC article.
Review.
Selective targeting of the αC and DFG-out pocket in p38 MAPK.
Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S.
Röhm S, et al. Among authors: widdowson cs.
Eur J Med Chem. 2020 Dec 15;208:112721. doi: 10.1016/j.ejmech.2020.112721. Epub 2020 Aug 20.
Eur J Med Chem. 2020.
PMID: 33035818
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Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells.
Davis T, Bagley MC, Dix MC, Murziani PG, Rokicki MJ, Widdowson CS, Zayed JM, Bachler MA, Kipling D.
Davis T, et al. Among authors: widdowson cs.
Bioorg Med Chem Lett. 2007 Dec 15;17(24):6832-5. doi: 10.1016/j.bmcl.2007.10.036. Epub 2007 Oct 17.
Bioorg Med Chem Lett. 2007.
PMID: 17964780
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Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing.
Bagley MC, Davis T, Dix MC, Widdowson CS, Kipling D.
Bagley MC, et al. Among authors: widdowson cs.
Org Biomol Chem. 2006 Nov 21;4(22):4158-64. doi: 10.1039/b611493h.
Org Biomol Chem. 2006.
PMID: 17312972
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Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors.
Davis T, Dix MC, Rokicki MJ, Brook AJ, Widdowson CS, Kipling D, Bagley MC.
Davis T, et al. Among authors: widdowson cs.
Chem Cent J. 2011 Dec 8;5(1):83. doi: 10.1186/1752-153X-5-83.
Chem Cent J. 2011.
PMID: 22152108
Free PMC article.
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Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome.
Bagley MC, Davis T, Rokicki MJ, Widdowson CS, Kipling D.
Bagley MC, et al. Among authors: widdowson cs.
Future Med Chem. 2010 Feb;2(2):193-201. doi: 10.4155/fmc.09.163.
Future Med Chem. 2010.
PMID: 21426186
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