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Page 1
Novel biologics targeting the P2X7 ion channel.
Koch-Nolte F, Eichhoff A, Pinto-Espinoza C, Schwarz N, Schäfer T, Menzel S, Haag F, Demeules M, Gondé H, Adriouch S. Koch-Nolte F, et al. Among authors: pinto espinoza c. Curr Opin Pharmacol. 2019 Aug;47:110-118. doi: 10.1016/j.coph.2019.03.001. Epub 2019 Apr 12. Curr Opin Pharmacol. 2019. PMID: 30986625 Review.
Modulating ion channel function with antibodies and nanobodies.
Stortelers C, Pinto-Espinoza C, Van Hoorick D, Koch-Nolte F. Stortelers C, et al. Among authors: pinto espinoza c. Curr Opin Immunol. 2018 Jun;52:18-26. doi: 10.1016/j.coi.2018.02.003. Epub 2018 Mar 23. Curr Opin Immunol. 2018. PMID: 29579624 Review.
Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions.
Wilmes M, Pinto Espinoza C, Ludewig P, Stabernack J, Liesz A, Nicke A, Gelderblom M, Gerloff C, Falzoni S, Tolosa E, Di Virgilio F, Rissiek B, Plesnilla N, Koch-Nolte F, Magnus T. Wilmes M, et al. Among authors: pinto espinoza c. J Neuroinflammation. 2022 Oct 12;19(1):256. doi: 10.1186/s12974-022-02601-z. J Neuroinflammation. 2022. PMID: 36224611 Free PMC article.
P2X7 is expressed on human innate-like T lymphocytes and mediates susceptibility to ATP-induced cell death.
Winzer R, Serracant-Prat A, Brock VJ, Pinto-Espinoza C, Rissiek B, Amadi M, Eich N, Rissiek A, Schneider E, Magnus T, Guse AH, Diercks BP, Koch-Nolte F, Tolosa E. Winzer R, et al. Among authors: pinto espinoza c. Eur J Immunol. 2022 Nov;52(11):1805-1818. doi: 10.1002/eji.202249932. Epub 2022 Oct 19. Eur J Immunol. 2022. PMID: 36178227 Free article.
Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs.
Pinto-Espinoza C, Guillou C, Rissiek B, Wilmes M, Javidi E, Schwarz N, Junge M, Haag F, Liaukouskaya N, Wanner N, Nicke A, Stortelers C, Tan YV, Adriouch S, Magnus T, Koch-Nolte F. Pinto-Espinoza C, et al. Front Pharmacol. 2022 Oct 10;13:1029236. doi: 10.3389/fphar.2022.1029236. eCollection 2022. Front Pharmacol. 2022. PMID: 36299894 Free PMC article.