Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.
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Bernard E, et al.
Nat Med. 2020 Oct;26(10):1549-1556. doi: 10.1038/s41591-020-1008-z. Epub 2020 Aug 3.
Nat Med. 2020.
PMID: 32747829
Free PMC article.
TP53 multi-hit state predicted risk of death and leukemic transformation independently of the Revised International Prognostic Scoring System (IPSS-R)(11). Surprisingly, monoallelic patients did not differ from TP53 wild-type patients in outcomes and response to therapy. . …
TP53 multi-hit state predicted risk of death and leukemic transformation independently of the Revised International Prognostic Scoring Syste …