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Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy.
Acosta MF, Muralidharan P, Grijalva CL, Abrahamson MD, Hayes D Jr, Fineman JR, Black SM, Mansour HM. Acosta MF, et al. Among authors: grijalva cl. Ther Adv Respir Dis. 2021 Jan-Dec;15:1753466621998245. doi: 10.1177/1753466621998245. Ther Adv Respir Dis. 2021. PMID: 33719747 Free PMC article.
Design and Comprehensive Characterization of Tetramethylpyrazine (TMP) for Targeted Lung Delivery as Inhalation Aerosols in Pulmonary Hypertension (PH): In Vitro Human Lung Cell Culture and In Vivo Efficacy.
Muralidharan P, Acosta MF, Gomez AI, Grijalva C, Tang H, Yuan JX, Mansour HM. Muralidharan P, et al. Among authors: grijalva c. Antioxidants (Basel). 2021 Mar 11;10(3):427. doi: 10.3390/antiox10030427. Antioxidants (Basel). 2021. PMID: 33799587 Free PMC article.
Comparison of l-Carnitine and l-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultures, and in vivo MCT-Rat model of PH.
Acosta MF, Muralidhran P, Abrahamson MD, Grijalva CL, Carver M, Tang H, Klinger C, Fineman JR, Black SM, Mansour HM. Acosta MF, et al. Among authors: grijalva cl. Pulm Pharmacol Ther. 2020 Dec;65:101998. doi: 10.1016/j.pupt.2021.101998. Epub 2021 Feb 5. Pulm Pharmacol Ther. 2020. PMID: 33556627 Free PMC article.