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Poly(I:C) promotes neurotoxic amyloid beta accumulation through reduced degradation by decreasing neprilysin protein levels in astrocytes.
Yamamoto N, Tokumon T, Obuchi A, Kono M, Saigo K, Tanida M, Ikeda-Matsuo Y, Sobue K. Yamamoto N, et al. J Neurochem. 2022 Dec;163(6):517-530. doi: 10.1111/jnc.15716. Epub 2022 Nov 16. J Neurochem. 2022. PMID: 36321194 Free article.
To this aim, primary rat primary astrocyte cultures were treated with poly(I:C) and inhibitors of the TLR3 signaling. Protein levels were assessed by Western blot. ...The degradation of exogenous Abeta was markedly delayed in poly(I:C)-treated astrocytes. This delay …
To this aim, primary rat primary astrocyte cultures were treated with poly(I:C) and inhibitors of the TLR3 signaling. Protein levels …
Evaluation of dissolution flux of iodine from brackish lake sediments under different temperature and oxygenic conditions.
Satoh Y, Imai S. Satoh Y, et al. Sci Total Environ. 2020 Mar 10;707:135920. doi: 10.1016/j.scitotenv.2019.135920. Epub 2019 Dec 14. Sci Total Environ. 2020. PMID: 31865086
The experiments were performed under three different temperatures (29, 17, and 6 C) and oxygenic (air flow, N(2) gas flow, and untreated) conditions for 48 h. ...Finally, the dissolution flux of radioiodine (iodine-129) from the sediments of Lake Obuchi to the overl …
The experiments were performed under three different temperatures (29, 17, and 6 C) and oxygenic (air flow, N(2) gas flow, and untrea …
Walking is regulated by environmental temperature.
Obuchi SP, Kawai H, Garbalosa JC, Nishida K, Murakawa K. Obuchi SP, et al. Sci Rep. 2021 Jun 9;11(1):12136. doi: 10.1038/s41598-021-91633-1. Sci Rep. 2021. PMID: 34108568 Free PMC article.

Observed walking speed and cadence were higher in winter (average maximum temperature: 10.2 C) than in summer (average maximum temperature: 29.8 C) (p < 0.001). ...A decrease in environmental temperature was found to increase cadence when the temperature was belo

…
Observed walking speed and cadence were higher in winter (average maximum temperature: 10.2 C) than in summer (average maximum temper …
Hyperstability and crystal structure of cytochrome c(555) from hyperthermophilic Aquifex aeolicus.
Obuchi M, Kawahara K, Motooka D, Nakamura S, Yamanaka M, Takeda T, Uchiyama S, Kobayashi Y, Ohkubo T, Sambongi Y. Obuchi M, et al. Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):804-13. doi: 10.1107/S0907444909017314. Epub 2009 Jul 17. Acta Crystallogr D Biol Crystallogr. 2009. PMID: 19622864
AA c(555) exhibited higher stability than the thermophilic Hydrogenobacter thermophilus cytochrome c(552) (HT c(552)), which is one of the most stable cytochromes c. ...The formation of the extra helix in AA c(555) results in the highest helix c …
AA c(555) exhibited higher stability than the thermophilic Hydrogenobacter thermophilus cytochrome c(552) (HT c(552)), …
Protein kinases A and C regulate amyloid-beta degradation by modulating protein levels of neprilysin and insulin-degrading enzyme in astrocytes.
Yamamoto N, Nakazawa M, Nunono N, Yoshida N, Obuchi A, Tanida M, Suzuki K, Ikeda-Matsuo Y, Sobue K. Yamamoto N, et al. Neurosci Res. 2021 May;166:62-72. doi: 10.1016/j.neures.2020.05.008. Epub 2020 Jun 5. Neurosci Res. 2021. PMID: 32512031
The pathology of sporadic Alzheimer's disease is hallmarked by altered signal transduction via the neurotransmitter receptor-G-protein-mediated protein kinase A (PKA) and protein kinase C (PKC) pathways. Because the accumulation of amyloid-beta (Abeta) depends on its rates …
The pathology of sporadic Alzheimer's disease is hallmarked by altered signal transduction via the neurotransmitter receptor-G-protein-media …
Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.
Abbott BP, Abbott R, Abbott TD, Abraham S, Acernese F, Ackley K, Adams C, Adya VB, Affeldt C, Agathos M, Agatsuma K, Aggarwal N, Aguiar OD, Aiello L, Ain A, Ajith P, Akutsu T, Allen G, Allocca A, Aloy MA, Altin PA, Amato A, Ananyeva A, Anderson SB, Anderson WG, Ando M, Angelova SV, Antier S, Appert S, Arai K, Arai K, Arai Y, Araki S, Araya A, Araya MC, Areeda JS, Arène M, Aritomi N, Arnaud N, Arun KG, Ascenzi S, Ashton G, Aso Y, Aston SM, Astone P, Aubin F, Aufmuth P, AultONeal K, Austin C, Avendano V, Avila-Alvarez A, Babak S, Bacon P, Badaracco F, Bader MKM, Bae SW, Bae YB, Baiotti L, Bajpai R, Baker PT, Baldaccini F, Ballardin G, Ballmer SW, Banagiri S, Barayoga JC, Barclay SE, Barish BC, Barker D, Barkett K, Barnum S, Barone F, Barr B, Barsotti L, Barsuglia M, Barta D, Bartlett J, Barton MA, Bartos I, Bassiri R, Basti A, Bawaj M, Bayley JC, Bazzan M, Bécsy B, Bejger M, Belahcene I, Bell AS, Beniwal D, Berger BK, Bergmann G, Bernuzzi S, Bero JJ, Berry CPL, Bersanetti D, Bertolini A, Betzwieser J, Bhandare R, Bidler J, Bilenko IA, Bilgili SA, Billingsley G, Birch J, Birney R, Birnholtz O, Biscans S, Biscoveanu S, Bisht A, Bitossi M, Bizouard MA, Blackburn JK, Blair CD, Blair DG,… See abstract for full author list ➔ Abbott BP, et al. Living Rev Relativ. 2020;23(1):3. doi: 10.1007/s41114-020-00026-9. Epub 2020 Sep 28. Living Rev Relativ. 2020. PMID: 33015351 Free PMC article. Review.
Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C.
Kuroda M, Niwa S, Sekizuka T, Tsukagoshi H, Yokoyama M, Ryo A, Sato H, Kiyota N, Noda M, Kozawa K, Shirabe K, Kusaka T, Shimojo N, Hasegawa S, Sugai K, Obuchi M, Tashiro M, Oishi K, Ishii H, Kimura H. Kuroda M, et al. Sci Rep. 2015 Feb 2;5:8185. doi: 10.1038/srep08185. Sci Rep. 2015. PMID: 25640899 Free PMC article.
Human rhinovirus species C (HRV-C) was recently discovered, and this virus has been associated with various acute respiratory illnesses (ARI). ...Thus, we performed complete VP1, VP2, and VP3 gene analyses of 139 clinical HRV-C strains using RT-PCR with newly …
Human rhinovirus species C (HRV-C) was recently discovered, and this virus has been associated with various acute respiratory …
DIRECT ASSIMILATION OF ATMOSPHERIC CARBON BY IMMATURE APPLE FRUITS.
Imada S, Tako Y, Moriya Y. Imada S, et al. Radiat Prot Dosimetry. 2022 Sep 9;198(13-15):1004-1008. doi: 10.1093/rpd/ncac034. Radiat Prot Dosimetry. 2022. PMID: 36083727
Although fruit development primarily depends on photoassimilation by leaves, immature green fruits can also directly assimilate atmospheric CO2. To elucidate the process of C accumulation due to direct assimilation by fruit, we conducted a 13CO2 exposure experiment in an o …
Although fruit development primarily depends on photoassimilation by leaves, immature green fruits can also directly assimilate atmospheric …
Development of a dynamic transfer model of (14)C from the atmosphere to rice plants.
Tani T, Arai R, Nozoe S, Tako Y, Takahashi T, Nakamura Y. Tani T, et al. J Environ Radioact. 2011 Apr;102(4):340-7. doi: 10.1016/j.jenvrad.2011.01.007. Epub 2011 Feb 22. J Environ Radioact. 2011. PMID: 21345551
A dynamic compartment model was investigated to describe (14)C accumulation in rice plants exposed to atmospheric (14)C with temporally changing concentrations. ...The model was examined by cultivation experiments using the stable isotope, (13)C, in which the …
A dynamic compartment model was investigated to describe (14)C accumulation in rice plants exposed to atmospheric (14)C with t …
Calorimetric characterization of critical targets for killing and acquired thermotolerance in yeast.
Obuchi K, Iwahashi H, Lepock JR, Komatsu Y. Obuchi K, et al. Yeast. 2000 Jan 30;16(2):111-9. doi: 10.1002/(SICI)1097-0061(20000130)16:2<111::AID-YEA507>3.0.CO;2-V. Yeast. 2000. PMID: 10641034
Whole-cell DSC profiles consisted of at least five endothermic components over the range 45-75 degrees C for exponentially growing, heat-shocked and stationary-phase cells. ...It was not possible unambiguously to resolve the profiles of the critical targets in the DSC scan …
Whole-cell DSC profiles consisted of at least five endothermic components over the range 45-75 degrees C for exponentially growing, h …
65 results