CNTO 530 increases expression of HbA and HbF in murine models of β-thalassemia and sickle cell anemia.
Makropoulos DA, Achuthanandam R, Avery J, Wilson K, Brosnan K, Miller A, Nesspor T, Chroscinski D, Walker M, Egenolf D, Huang C, Bugelski PJ.
Makropoulos DA, et al.
Curr Pharm Biotechnol. 2013;14(2):242-8. doi: 10.2174/138920113805219449.
Curr Pharm Biotechnol. 2013.
PMID: 23157711
Free PMC article.
To test the effectiveness of CNTO 530, mice from both genotypes received a single subcutaneous (s.c.) dose of CNTO 530 or darbepoetin-alpha (as a comparator) at 10,000 U/kg, a dose shown to cause a similar increase in reticulocytes and hemoglobin in normal mice. ...
To test the effectiveness of CNTO 530, mice from both genotypes received a single subcutaneous (s.c.) dose of CNTO 530 or darbepoetin …