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Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics.
Yang S, DeMars MD 2nd, Grandner JM, Olson NM, Anzai Y, Sherman DH, Houk KN. Yang S, et al. J Am Chem Soc. 2020 Oct 21;142(42):17981-17988. doi: 10.1021/jacs.0c04388. Epub 2020 Oct 8. J Am Chem Soc. 2020. PMID: 33030347 Free PMC article.
MycG is a cytochrome P450 that performs two sequential oxidation reactions on the 16-membered ring macrolide M-IV. The enzyme evolved to oxidize M-IV preferentially over M-III and M-VI, which differ only by the presence of methoxy vs free hydroxyl grou …
MycG is a cytochrome P450 that performs two sequential oxidation reactions on the 16-membered ring macrolide M-IV. The enzyme evolved …
Shedding of Brucella melitensis happens through milk macrophages in the murine model of infection.
Jansen W, Demars A, Nicaise C, Godfroid J, de Bolle X, Reboul A, Al Dahouk S. Jansen W, et al. Sci Rep. 2020 Jun 10;10(1):9421. doi: 10.1038/s41598-020-65760-0. Sci Rep. 2020. PMID: 32523093 Free PMC article.
Pregnant Balb/cByJ mice were intraperitoneally infected with 10(5) CFU of the 16 M reference strain, a 16 M mCherry mutant or a human isolate. Milk was collected over the course of lactation, and subjected to culture and immunofluorescence assays. ...
Pregnant Balb/cByJ mice were intraperitoneally infected with 10(5) CFU of the 16 M reference strain, a 16 M mCherry mutant or …
Allergic Asthma Favors Brucella Growth in the Lungs of Infected Mice.
Machelart A, Potemberg G, Van Maele L, Demars A, Lagneaux M, De Trez C, Sabatel C, Bureau F, De Prins S, Percier P, Denis O, Jurion F, Romano M, Vanderwinden JM, Letesson JJ, Muraille E. Machelart A, et al. Front Immunol. 2018 Aug 10;9:1856. doi: 10.3389/fimmu.2018.01856. eCollection 2018. Front Immunol. 2018. PMID: 30147700 Free PMC article.
Surprisingly, we observed that Alt sensitization strongly increases the survival of S. pneumoniae infected mice by a T cell and STAT6 independent signaling pathway. In contrast, the course of M. tuberculosis infection is not affected in the lungs of sensitized mice. ...
Surprisingly, we observed that Alt sensitization strongly increases the survival of S. pneumoniae infected mice by a T cell and STAT6 indepe …
Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.
Lowell AN, DeMars MD 2nd, Slocum ST, Yu F, Anand K, Chemler JA, Korakavi N, Priessnitz JK, Park SR, Koch AA, Schultz PJ, Sherman DH. Lowell AN, et al. J Am Chem Soc. 2017 Jun 14;139(23):7913-7920. doi: 10.1021/jacs.7b02875. Epub 2017 Jun 5. J Am Chem Soc. 2017. PMID: 28525276 Free PMC article.
We explored the functionality of two terminal PKS modules that produce the 16-membered tylosin macrocycle, using them as biocatalysts in the chemoenzymatic synthesis of tylactone and its subsequent elaboration to complete the first total synthesis of the juvenimicin, M-436 …
We explored the functionality of two terminal PKS modules that produce the 16-membered tylosin macrocycle, using them as biocatalysts in the …
Insulin binding to human B lymphoblasts is a function of HLA haplotype.
Kittur D, Shimizu Y, DeMars R, Edidin M. Kittur D, et al. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1351-5. doi: 10.1073/pnas.84.5.1351. Proc Natl Acad Sci U S A. 1987. PMID: 3547409 Free PMC article.
The affinity, Ka, of insulin binding sites is approximately 10(8) M-1 in mutants expressing antigen HLA-B5 together with other HLA antigens and in mutants expressing only HLA-C. HLA-A1; HLA-A1,B8; HLA-A2,C; and HLA null mutants (not expressing any HLA antigen …
The affinity, Ka, of insulin binding sites is approximately 10(8) M-1 in mutants expressing antigen HLA-B5 together with other HLA an …
Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulin.
Hochman JH, Shimizu Y, DeMars R, Edidin M. Hochman JH, et al. J Immunol. 1988 Apr 1;140(7):2322-9. J Immunol. 1988. PMID: 2450918
We determined the kinetic and equilibrium binding parameters for the fluorescent b2m derivatives associating with the class I H chains of mouse and human cells. Peaks B and C exhibited biphasic binding to the mouse lymphoma cells EL-4(G-CSA-) (Kd1 = 1 x 10(-9) M; K2 …
We determined the kinetic and equilibrium binding parameters for the fluorescent b2m derivatives associating with the class I H chains of mo …
River sediments provide a link between catchment pressures and ecological status in a mixed land use Scottish River system.
Stutter MI, Langan SJ, Demars BO. Stutter MI, et al. Water Res. 2007 Jun;41(12):2803-15. doi: 10.1016/j.watres.2007.03.006. Epub 2007 Apr 19. Water Res. 2007. PMID: 17448517
SPM was 7-372 times enriched in biologically available P (BAP; determined using an FeO paper strip method) and 2-122 times in organic C relative to bed sediments. Ratios in river water concentrations of BAP attributed to the SPM (0.1-1.0 microgPl(-1)) to PO(4)-P had the gr …
SPM was 7-372 times enriched in biologically available P (BAP; determined using an FeO paper strip method) and 2-122 times in organic C