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Comprehensive discovery of novel structured noncoding RNAs in 26 bacterial genomes.
Brewer KI, Greenlee EB, Higgs G, Yu D, Mirihana Arachchilage G, Chen X, King N, White N, Breaker RR. Brewer KI, et al. RNA Biol. 2021 Dec;18(12):2417-2432. doi: 10.1080/15476286.2021.1917891. Epub 2021 May 10. RNA Biol. 2021. PMID: 33970790 Free PMC article.
This search process exploits the fact that genomic regions serving as templates for the transcription of structured RNAs tend to be present in longer than average noncoding 'intergenic regions' (IGRs) that are enriched in G and C nucleotides compared to the remainder of th …
This search process exploits the fact that genomic regions serving as templates for the transcription of structured RNAs tend to be present …
Challenges of ligand identification for the second wave of orphan riboswitch candidates.
Greenlee EB, Stav S, Atilho RM, Brewer KI, Harris KA, Malkowski SN, Mirihana Arachchilage G, Perkins KR, Sherlock ME, Breaker RR. Greenlee EB, et al. Among authors: brewer ki. RNA Biol. 2018 Mar 4;15(3):377-390. doi: 10.1080/15476286.2017.1403002. Epub 2018 Feb 1. RNA Biol. 2018. PMID: 29135333 Free PMC article.
This facilitated the validation of riboswitches for the signaling molecules c-di-AMP, ZTP, and ppGpp, the metal ion Mn(2+), and the metabolites guanidine and PRPP. ...
This facilitated the validation of riboswitches for the signaling molecules c-di-AMP, ZTP, and ppGpp, the metal ion Mn(2+), and the m …