Targeting the Human beta(c) Receptor Inhibits Contact Dermatitis in a Transgenic Mouse Model.
Yip KH, McKenzie D, Ramshaw HS, Chao J, McClure BJ, Raquet E, Kraushaar T, Röder J, Maxwell M, Alhamdoosh M, Hammet A, Fong JH, Zeglinski K, Monaghan K, Pant H, Grimbaldeston MA, Vairo G, Wilson NJ, Owczarek CM, Hercus TR, Lopez AF, Tumes DJ.
Yip KH, et al.
J Invest Dermatol. 2022 Apr;142(4):1103-1113.e11. doi: 10.1016/j.jid.2021.07.183. Epub 2021 Sep 17.
J Invest Dermatol. 2022.
PMID: 34537191
Free article.
However, the species specificity of beta(c) has precluded testing of inhibitors of human beta(c) in mouse models. To overcome this problem, we developed a human beta(c) receptor transgenic mouse strain with a hematopoietic cell-specific expression of human be …
However, the species specificity of beta(c) has precluded testing of inhibitors of human beta(c) in mouse models. To overcome …