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2002 3
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2019 1
2020 2
2022 1
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Page 1
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
STARSurg Collaborative and EuroSurg Collaborative. STARSurg Collaborative and EuroSurg Collaborative. BJS Open. 2022 Jan 6;6(1):zrab150. doi: 10.1093/bjsopen/zrab150. BJS Open. 2022. PMID: 35179188 Free PMC article.
Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655-0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323-0.352 (IMAGINE 9 …
Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655-0.681 (Tays …
Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery.
EuroSurg Collaborative. EuroSurg Collaborative. Br J Surg. 2020 Jan;107(2):e161-e169. doi: 10.1002/bjs.11326. Epub 2019 Oct 9. Br J Surg. 2020. PMID: 31595986 Free article.
After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4.6 versus 4.8 days; hazard ratio 1.04, 95 per cent c.i. 0.96 to 1.12; P = 0.360). There were no s …
After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who rece …
Safety of hospital discharge before return of bowel function after elective colorectal surgery.
EuroSurg Collaborative. EuroSurg Collaborative. Br J Surg. 2020 Apr;107(5):552-559. doi: 10.1002/bjs.11422. Epub 2020 Jan 24. Br J Surg. 2020. PMID: 31976560
There were no significant differences in rates of readmission between these groups (6.6 versus 8.0 per cent; P = 0.499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0.90, 95 per cent c.i. 0.55 to 1.46; P = 0.659). Rates of …
There were no significant differences in rates of readmission between these groups (6.6 versus 8.0 per cent; P = 0.499), and this remained t …
Trypsin-like proteinase produced by Fusarium culmorum grown on grain proteins.
Pekkarinen AI, Jones BL. Pekkarinen AI, et al. J Agric Food Chem. 2002 Jun 19;50(13):3849-55. doi: 10.1021/jf020027x. J Agric Food Chem. 2002. PMID: 12059170
A trypsin-like proteinase has been purified from a gluten-containing culture medium of F. culmorum. The enzyme was maximally active at about pH 9 and 45 degrees C, but was not stable under those conditions. It was stabilized by calcium ions and by the presence of other pro …
A trypsin-like proteinase has been purified from a gluten-containing culture medium of F. culmorum. The enzyme was maximally active at about …
Purification and properties of an alkaline proteinase of Fusarium culmorum.
Pekkarinen AI, Jones BL, Niku-Paavola ML. Pekkarinen AI, et al. Eur J Biochem. 2002 Feb;269(3):798-807. doi: 10.1046/j.0014-2956.2001.02697.x. Eur J Biochem. 2002. PMID: 11846781 Free article.
To do this, Fusarium culmorum was grown in a gluten-containing medium from which an alkaline serine proteinase with a molecular mass of 28.7 kDa was purified by size-exclusion and cation exchange chromatographies. The enzyme was maximally active at pH 8.3-9.6 and 50 degrees C …
To do this, Fusarium culmorum was grown in a gluten-containing medium from which an alkaline serine proteinase with a molecular mass of 28.7 …
SEP-1 - a subtilisin-like serine endopeptidase from germinated seeds of Hordeum vulgare L. cv. Morex.
Fontanini D, Jones BL. Fontanini D, et al. Planta. 2002 Oct;215(6):885-93. doi: 10.1007/s00425-002-0823-4. Epub 2002 Jul 13. Planta. 2002. PMID: 12355148
The hydrolysis of the synthetic substrate was optimal at pH 6.5 and 50 degrees C with a K(m) of 2.6 mM. The enzyme was inhibited by phenylmethylsulfonyl fluoride and p-amidinophenyl methanesulfonyl fluoride but not by any other class-specific inhibitor, suggesting it was a …
The hydrolysis of the synthetic substrate was optimal at pH 6.5 and 50 degrees C with a K(m) of 2.6 mM. The enzyme was inhibited by p …