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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
1959 2
1974 1
1975 1
1976 1
1977 1
1978 1
1979 2
1980 4
1981 5
1982 11
1983 11
1984 11
1985 10
1986 19
1987 15
1988 25
1989 42
1990 32
1991 35
1992 53
1993 51
1994 66
1995 77
1996 85
1997 107
1998 114
1999 120
2000 125
2001 160
2002 138
2003 132
2004 156
2005 174
2006 176
2007 196
2008 196
2009 216
2010 293
2011 248
2012 268
2013 279
2014 326
2015 368
2016 422
2017 421
2018 464
2019 463
2020 473
2021 471
2022 450
2023 429
2024 157

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7,163 results

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Page 1
Angiotensin II-Induced Signal Transduction Mechanisms for Cardiac Hypertrophy.
Bhullar SK, Dhalla NS. Bhullar SK, et al. Cells. 2022 Oct 22;11(21):3336. doi: 10.3390/cells11213336. Cells. 2022. PMID: 36359731 Free PMC article. Review.
It is now evident that the hypertrophic response is mediated by the activation of Ang type 1 receptors (AT(1)R), whereas the activation of Ang type 2 receptors (AT(2)R) by Ang II and Mas receptors by Ang-(1-7) exerts antihypertrophic effects. Furthermo …
It is now evident that the hypertrophic response is mediated by the activation of Ang type 1 receptors (AT(1)R), whereas the activati …
Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-kappaB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1-7 Signals.
Kamel EO, Gad-Elrab WM, Ahmed MA, Mohammedsaleh ZM, Hassanein EHM, Ali FEM. Kamel EO, et al. Biol Trace Elem Res. 2023 Apr;201(4):1846-1863. doi: 10.1007/s12011-022-03286-4. Epub 2022 May 19. Biol Trace Elem Res. 2023. PMID: 35590119 Free PMC article.
Moreover, candesartan attenuated Cd hepatorenal apoptosis by upregulating Bcl-2 and downregulating Bax and Cyt-C proteins. Interestingly, these effects are suggested to be an outcome of modulating of Ang II/Ang 1-7 signal. Overall, our findings revealed that …
Moreover, candesartan attenuated Cd hepatorenal apoptosis by upregulating Bcl-2 and downregulating Bax and Cyt-C proteins. Interestin …
Role of c-Abl in Ang II-induced aortic dissection formation: Potential regulatory efficacy on phenotypic transformation and apoptosis of VSMCs.
Zhou X, Cheng J, Chen Z, Li H, Chen S, Xu F, Fan R, Zhuang J, Sun T. Zhou X, et al. Life Sci. 2020 Sep 1;256:117882. doi: 10.1016/j.lfs.2020.117882. Epub 2020 Jun 1. Life Sci. 2020. PMID: 32497633
MAIN METHODS: Lentiviral transfection and short hairpin RNA (shRNA) were used to enhance or inhibit c-Abl in cultured VSMCs. In addition, C57BL/6 and Abl1 gene knockout heterozygous (c-Abl(-/+)) mice were infused with Ang II, with or without c-Abl inhi …
MAIN METHODS: Lentiviral transfection and short hairpin RNA (shRNA) were used to enhance or inhibit c-Abl in cultured VSMCs. In addit …
Angiotensin (ang) 1-7 inhibits ang II-induced atrial fibrosis through regulating the interaction of proto-oncogene tyrosine-protein kinase Src (c-Src) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)).
Lu L, Cao L, Liu Y, Chen Y, Fan J, Yin Y. Lu L, et al. Bioengineered. 2021 Dec;12(2):10823-10836. doi: 10.1080/21655979.2021.1967035. Bioengineered. 2021. PMID: 34872449 Free PMC article.
Ang II-induced HL-1 cell model and a rat model of Ang II-induced atrial remodeling were constructed and intervened with Ang II Ang-(1-7), AngII +Ang-(1-7), Ang II+ c-Src specific inhibitor (SU6656), and Ang II + Ang-( …
Ang II-induced HL-1 cell model and a rat model of Ang II-induced atrial remodeling were constructed and intervened with Ang …
c-Jun/Ap-1 is upregulated in an Ang II-induced abdominal aortic aneurysm formation model and mediates Chop expression in mouse aortic smooth muscle cells.
Sun D, Zhang M, Li Y, Mei S, Qin J, Yan J. Sun D, et al. Mol Med Rep. 2019 May;19(5):3459-3468. doi: 10.3892/mmr.2019.10017. Epub 2019 Mar 12. Mol Med Rep. 2019. PMID: 30864718 Free PMC article.
The purpose of the present study was to investigate whether c-Jun/AP-1 mediates Chop overexpression in AAA. c-Jun/AP-1 and Chop protein levels were determined in an angiotensin II (Ang II)-induced AAA model using apolipoprotein E-deficient mice. ...It was obs …
The purpose of the present study was to investigate whether c-Jun/AP-1 mediates Chop overexpression in AAA. c-Jun/AP-1 and Cho …
Diacerein alleviates Ang II-induced cardiac inflammation and remodeling by inhibiting the MAPKs/c-Myc pathway.
Wang M, Luo W, Yu T, Liang S, Zou C, Sun J, Li G, Liang G. Wang M, et al. Phytomedicine. 2022 Nov;106:154387. doi: 10.1016/j.phymed.2022.154387. Epub 2022 Aug 12. Phytomedicine. 2022. PMID: 36027716
We further confirmed that diacerein inhibits Ang II-activated MAPKs/c-Myc pathway to reduce inflammatory response in mouse hearts and cultured cardiomyocytes. ...CONCLUSION: Our results indicate that diacerein protects hearts in Ang II-induced mice through in …
We further confirmed that diacerein inhibits Ang II-activated MAPKs/c-Myc pathway to reduce inflammatory response in mouse hea …
NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II-Mediated Atrial Fibrillation and Atrial Remodeling in Mice.
Jansen HJ, Mackasey M, Moghtadaei M, Liu Y, Kaur J, Egom EE, Tuomi JM, Rafferty SA, Kirkby AW, Rose RA. Jansen HJ, et al. Circ Arrhythm Electrophysiol. 2019 Jan;12(1):e006863. doi: 10.1161/CIRCEP.118.006863. Circ Arrhythm Electrophysiol. 2019. PMID: 30636477
These effects were exacerbated in Ang II-treated NPR-C(-/-) mice. Ang II prolonged action potential duration and reduced action potential upstroke velocity (V(max)). These effects were greater in left atrial myocytes from Ang II-treated NPR-C(-/ …
These effects were exacerbated in Ang II-treated NPR-C(-/-) mice. Ang II prolonged action potential duration and reduce …
c-Abl mediates angiotensin II-induced apoptosis in podocytes.
Chen X, Ren Z, Liang W, Zha D, Liu Y, Chen C, Singhal PC, Ding G. Chen X, et al. J Mol Histol. 2013 Oct;44(5):597-608. doi: 10.1007/s10735-013-9505-8. Epub 2013 Mar 21. J Mol Histol. 2013. PMID: 23515840 Free PMC article.
Ang II-receiving rats displayed enhanced podocyte c-Abl expression. ...These findings indicate that c-Abl may mediates Ang II-induced podocyte apoptosis, and inhibition of c-Abl expression can protect podocytes from Ang II-induced injury. …
Ang II-receiving rats displayed enhanced podocyte c-Abl expression. ...These findings indicate that c-Abl may mediates …
Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice.
Mackasey M, Egom EE, Jansen HJ, Hua R, Moghtadaei M, Liu Y, Kaur J, McRae MD, Bogachev O, Rafferty SA, Ray G, Kirkby AW, Rose RA. Mackasey M, et al. JACC Basic Transl Sci. 2018 Dec 5;3(6):824-843. doi: 10.1016/j.jacbts.2018.08.004. eCollection 2018 Dec. JACC Basic Transl Sci. 2018. PMID: 30623142 Free PMC article.
Strikingly, Ang II treatment in NPR-C(-/-) mice worsened SAN disease, whereas co-treatment of wild-type mice with Ang II and a selective NPR-C agonist (cANF) prevented SAN dysfunction. NPR-C may represent a new target to protect against the deve …
Strikingly, Ang II treatment in NPR-C(-/-) mice worsened SAN disease, whereas co-treatment of wild-type mice with Ang I …
Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells.
Yogi A, Callera GE, Montezano AC, Aranha AB, Tostes RC, Schiffrin EL, Touyz RM. Yogi A, et al. Arterioscler Thromb Vasc Biol. 2007 Sep;27(9):1960-7. doi: 10.1161/ATVBAHA.107.146746. Epub 2007 Jun 14. Arterioscler Thromb Vasc Biol. 2007. PMID: 17569879
Ang II but not ET-1 induced c-Src phosphorylation in c-Src(+/+) VSMCs. ...Ang II but not ET-1-mediated c-Raf phosphorylation was inhibited by c-Src deficiency. ...
Ang II but not ET-1 induced c-Src phosphorylation in c-Src(+/+) VSMCs. ...Ang II but not ET-1-mediated c- …
7,163 results