Pluronic®/casein micelles for ophthalmic delivery of resveratrol: In vitro, ex vivo, and in vivo tests.
Vivero-Lopez M, Sparacino C, Quelle-Regaldie A, Sánchez L, Candal E, Barreiro-Iglesias A, Huete-Toral F, Carracedo G, Otero A, Concheiro A, Alvarez-Lorenzo C.
Vivero-Lopez M, et al.
Int J Pharm. 2022 Nov 25;628:122281. doi: 10.1016/j.ijpharm.2022.122281. Epub 2022 Oct 13.
Int J Pharm. 2022.
PMID: 36243323
Free article.
Single and mixed (0.1 % casein) micelles (0.0 to -17.0 mV; 2.4 to 32.7 nm) increased 50-fold resveratrol solubility, remained stable for one month at 4 C, withstood fast dilution, underwent sol-to-gel transitions in the 23.9-27.1 C range, and exhibited potent antiox …
Single and mixed (0.1 % casein) micelles (0.0 to -17.0 mV; 2.4 to 32.7 nm) increased 50-fold resveratrol solubility, remained stable for one …