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GIV/Girdin activates Gαi and inhibits Gαs via the same motif.
Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. Gupta V, et al. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub 2016 Sep 12. Proc Natl Acad Sci U S A. 2016. PMID: 27621449 Free PMC article.
We previously showed that guanine nucleotide-binding (G) protein alpha subunit (Galpha)-interacting vesicle-associated protein (GIV), a guanine-nucleotide exchange factor (GEF), transactivates Galpha activity-inhibiting polypeptide 1 (Galphai) proteins in response to growth facto …
We previously showed that guanine nucleotide-binding (G) protein alpha subunit (Galpha)-interacting vesicle-associated protein (GIV), a guan …
Protein kinase C-theta (PKCteta) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin.
López-Sánchez I, Garcia-Marcos M, Mittal Y, Aznar N, Farquhar MG, Ghosh P. López-Sánchez I, et al. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5510-5. doi: 10.1073/pnas.1303392110. Epub 2013 Mar 18. Proc Natl Acad Sci U S A. 2013. PMID: 23509302 Free PMC article.
Site-directed mutations in GIV's GEF motif disrupt its ability to bind or activate Gi and abrogate PI3K-Akt signals; however, nothing is known about how GIV's GEF function is regulated. Here we report that PKCteta, a novel protein kinase C, down-regulates GIV's GEF functio …
Site-directed mutations in GIV's GEF motif disrupt its ability to bind or activate Gi and abrogate PI3K-Akt signals; however, nothing is kno …
Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.
Ma GS, Aznar N, Kalogriopoulos N, Midde KK, Lopez-Sanchez I, Sato E, Dunkel Y, Gallo RL, Ghosh P. Ma GS, et al. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2602-10. doi: 10.1073/pnas.1505543112. Epub 2015 Apr 29. Proc Natl Acad Sci U S A. 2015. PMID: 25926659 Free PMC article.
This paradigm has recently been challenged by several studies on a multimodular signal transducer, Galpha-Interacting Vesicle associated protein (GIV/Girdin). We recently demonstrated that GIV's C terminus (CT) serves as a platform for dynamic association of ligand-activat …
This paradigm has recently been challenged by several studies on a multimodular signal transducer, Galpha-Interacting Vesicle associated pro …