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Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis.
Kalpage HA, Bazylianska V, Recanati MA, Fite A, Liu J, Wan J, Mantena N, Malek MH, Podgorski I, Heath EI, Vaishnav A, Edwards BF, Grossman LI, Sanderson TH, Lee I, Hüttemann M. Kalpage HA, et al. FASEB J. 2019 Feb;33(2):1540-1553. doi: 10.1096/fj.201801417R. Epub 2018 Sep 17. FASEB J. 2019. PMID: 30222078 Free PMC article. Review.
Cytochrome c (Cyt c) plays a vital role in the mitochondrial electron transport chain (ETC). ...-Kalpage, H. A., Bazylianska, V., Recanati, M. A., Fite, A., Liu, J., Wan, J., Mantena, N., Malek, M. ...
Cytochrome c (Cyt c) plays a vital role in the mitochondrial electron transport chain (ETC). ...-Kalpage, H. A., Bazyli …
Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy.
Carter JL, Hege K, Yang J, Kalpage HA, Su Y, Edwards H, Hüttemann M, Taub JW, Ge Y. Carter JL, et al. Signal Transduct Target Ther. 2020 Dec 18;5(1):288. doi: 10.1038/s41392-020-00361-x. Signal Transduct Target Ther. 2020. PMID: 33335095 Free PMC article. Review.
Here we review the development of novel therapeutics in targeting apoptosis, receptor tyrosine kinase (RTK) signaling, hedgehog (HH) pathway, mitochondrial function, DNA repair, and c-Myc signaling. There has been an impressive effort into better understanding the diversit …
Here we review the development of novel therapeutics in targeting apoptosis, receptor tyrosine kinase (RTK) signaling, hedgehog (HH) pathway …
Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle.
Morse PT, Pérez-Mejías G, Wan J, Turner AA, Márquez I, Kalpage HA, Vaishnav A, Zurek MP, Huettemann PP, Kim K, Arroum T, De la Rosa MA, Chowdhury DD, Lee I, Brunzelle JS, Sanderson TH, Malek MH, Meierhofer D, Edwards BFP, Díaz-Moreno I, Hüttemann M. Morse PT, et al. Nat Commun. 2023 Jul 13;14(1):4166. doi: 10.1038/s41467-023-39820-8. Nat Commun. 2023. PMID: 37443314 Free PMC article.
Tissue specific post-translational modifications of cytochrome c (Cytc) are involved in ischemia-reperfusion injury by regulating mitochondrial respiration and apoptosis. ...Using purified protein and cellular double knockout models, we show that K39 acetylation and acetyl …
Tissue specific post-translational modifications of cytochrome c (Cytc) are involved in ischemia-reperfusion injury by regulating mit …
Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity.
Kalpage HA, Vaishnav A, Liu J, Varughese A, Wan J, Turner AA, Ji Q, Zurek MP, Kapralov AA, Kagan VE, Brunzelle JS, Recanati MA, Grossman LI, Sanderson TH, Lee I, Salomon AR, Edwards BFP, Hüttemann M. Kalpage HA, et al. FASEB J. 2019 Dec;33(12):13503-13514. doi: 10.1096/fj.201901120R. Epub 2019 Sep 28. FASEB J. 2019. PMID: 31570002 Free PMC article.
Cytochrome c (Cytc) is a multifunctional protein that operates as an electron carrier in the mitochondrial electron transport chain and plays a key role in apoptosis. ...R., Edwards, B. F. P, Huttemann, M. Serine-47 phosphorylation of cytochrome c in the mammalian b …
Cytochrome c (Cytc) is a multifunctional protein that operates as an electron carrier in the mitochondrial electron transport chain a …
Co-targeting of HDAC, PI3K, and Bcl-2 results in metabolic and transcriptional reprogramming and decreased mitochondrial function in acute myeloid leukemia.
Hege Hurrish K, Qiao X, Li X, Su Y, Carter J, Ma J, Kalpage HA, Hüttemann M, Edwards H, Wang G, Kim S, Dombkowski A, Bao X, Li J, Taub JW, Ge Y. Hege Hurrish K, et al. Biochem Pharmacol. 2022 Nov;205:115283. doi: 10.1016/j.bcp.2022.115283. Epub 2022 Oct 5. Biochem Pharmacol. 2022. PMID: 36208684 Free PMC article.
Our lab has previously demonstrated the promising outlook for CUDC-907, a dual inhibitor of PI3K and HDAC, in combination with venetoclax (VEN), against AML both in vitro and in vivo at least partially through suppression of c-Myc. In this study, we further elucidated the …
Our lab has previously demonstrated the promising outlook for CUDC-907, a dual inhibitor of PI3K and HDAC, in combination with venetoclax (V …
Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis.
Bazylianska V, Kalpage HA, Wan J, Vaishnav A, Mahapatra G, Turner AA, Chowdhury DD, Kim K, Morse PT, Lee I, Brunzelle JS, Polin L, Subedi P, Heath EI, Podgorski I, Marcus K, Edwards BFP, Hüttemann M. Bazylianska V, et al. Cells. 2021 Apr 3;10(4):802. doi: 10.3390/cells10040802. Cells. 2021. PMID: 33916826 Free PMC article.
Two classic cancer hallmarks are a metabolic switch from oxidative phosphorylation (OxPhos) to glycolysis, known as the Warburg effect, and resistance to cell death. Cytochrome c (Cytc) is at the intersection of both pathways, as it is essential for electron transport in m …
Two classic cancer hallmarks are a metabolic switch from oxidative phosphorylation (OxPhos) to glycolysis, known as the Warburg effect, and …
Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis.
Kalpage HA, Wan J, Morse PT, Zurek MP, Turner AA, Khobeir A, Yazdi N, Hakim L, Liu J, Vaishnav A, Sanderson TH, Recanati MA, Grossman LI, Lee I, Edwards BFP, Hüttemann M. Kalpage HA, et al. Int J Biochem Cell Biol. 2020 Apr;121:105704. doi: 10.1016/j.biocel.2020.105704. Epub 2020 Feb 2. Int J Biochem Cell Biol. 2020. PMID: 32023432 Free PMC article.
Cytochrome c (Cytc)(1)is a cellular life and death decision molecule that regulates cellular energy supply and apoptosis through tissue specific post-translational modifications. ...We here present a new model proposing that the electron transfer from Cytc to cytochrome …
Cytochrome c (Cytc)(1)is a cellular life and death decision molecule that regulates cellular energy supply and apoptosis through tiss …
Brain-Specific Serine-47 Modification of Cytochrome c Regulates Cytochrome c Oxidase Activity Attenuating ROS Production and Cell Death: Implications for Ischemia/Reperfusion Injury and Akt Signaling.
Kalpage HA, Wan J, Morse PT, Lee I, Hüttemann M. Kalpage HA, et al. Cells. 2020 Aug 6;9(8):1843. doi: 10.3390/cells9081843. Cells. 2020. PMID: 32781572 Free PMC article.
We previously reported that serine-47 (S47) phosphorylation of cytochrome c (Cytc) in the brain results in lower cytochrome c oxidase (COX) activity and caspase-3 activity in vitro. ...
We previously reported that serine-47 (S47) phosphorylation of cytochrome c (Cytc) in the brain results in lower cytochrome c
Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation.
Liu F, Kalpage HA, Wang D, Edwards H, Hüttemann M, Ma J, Su Y, Carter J, Li X, Polin L, Kushner J, Dzinic SH, White K, Wang G, Taub JW, Ge Y. Liu F, et al. Cancers (Basel). 2020 Aug 24;12(9):2400. doi: 10.3390/cancers12092400. Cancers (Basel). 2020. PMID: 32847115 Free PMC article.
However, complex I deficiency has been reported to inhibit apoptotic cell death through prevention of cytochrome c release. Thus, combining IACS-010759 with a BH3 mimetic may overcome this mechanism of resistance leading to synergistic antileukemic activity against AML. .. …
However, complex I deficiency has been reported to inhibit apoptotic cell death through prevention of cytochrome c release. Thus, com …