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Multiscale Computer Modeling of Spreading Depolarization in Brain Slices.
Kelley C, Newton AJH, Hrabetova S, McDougal RA, Lytton WW. Kelley C, et al. eNeuro. 2022 Aug 18;9(4):ENEURO.0082-22.2022. doi: 10.1523/ENEURO.0082-22.2022. Print 2022 Jul-Aug. eNeuro. 2022. PMID: 35927026 Free PMC article.
We developed multiscale (ions to tissue slice) computer models of SD in brain slices using the NEURON simulator: 36,000 neurons (two voltage-gated ion channels; three leak channels; three ion exchangers/pumps) in the extracellular space (ECS) of a slice (1 mm sides, varyin …
We developed multiscale (ions to tissue slice) computer models of SD in brain slices using the NEURON simulator: 36,000 neurons (two …
Longitudinal Gray Matter Trajectories in Pediatric Mild Traumatic Brain Injury.
Ware AL, Lebel C, Onicas A, Abdeen N, Beauchamp MH, Beaulieu C, Bjornson BH, Craig W, Dehaes M, Doan Q, Deschenes S, Freedman SB, Goodyear BG, Gravel J, Ledoux AA, Zemek R, Yeates KO; Pediatric Emergency Research Canada A-CAP Study Group. Ware AL, et al. Neurology. 2023 Aug 15;101(7):e728-e739. doi: 10.1212/WNL.0000000000207508. Epub 2023 Jun 23. Neurology. 2023. PMID: 37353339
BACKGROUND AND OBJECTIVES: This prospective, longitudinal cohort study examined trajectories of brain gray matter macrostructure after pediatric mild traumatic brain injury (mTBI). ...RESULTS: Groups (N = 623; 407 mTBI/216 OI; 59% male; age mean = 12.03, SD = 2.38 y …
BACKGROUND AND OBJECTIVES: This prospective, longitudinal cohort study examined trajectories of brain gray matter macrostructure afte …
Receptor binding of somatostatin-14 and somatostatin-28 in rat brain: differential modulation by nucleotides and ions.
Srikant CB, Dahan A, Craig C. Srikant CB, et al. Regul Pept. 1990 Feb 4;27(2):181-94. doi: 10.1016/0167-0115(90)90038-x. Regul Pept. 1990. PMID: 1970185
The tissue-selective binding of the two principal bioactive forms of somatostatin, somatostatin-14 (SS-14) and somatostatin-28 (SS-28), their ability to modulate cAMP-dependent and -independent regulation of post-receptor events to different degrees and the documentation of speci …
The tissue-selective binding of the two principal bioactive forms of somatostatin, somatostatin-14 (SS-14) and somatostatin-28 (SS-28), thei …